Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon
Abstract Background Anti-phospholipid syndrome (APLS) is a condition characterized by the presence of raised plasma levels of anti-phospholipid antibodies associated with thrombo-embolic disease and/or poor obstetrical outcomes in women. The epidemiology of APLS is unknown in most sub-Saharan Africa...
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doaj-1185831e84844638ae92c88b49c50ba52020-11-25T03:27:50ZengBMCBMC Research Notes1756-05002017-08-011011410.1186/s13104-017-2689-3Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from CameroonAhmadou M. Jingi0Liliane Mfeukeu-Kuate1Aurel T. Tankeu2Narcisse Assene Ateba3Edvine Wawo Yonta4Jean Jacques Noubiap5Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé IDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé IDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé IDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé IDepartment of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé IDepartment of Medicine, University of Cape Town and Groote Schuur HospitalAbstract Background Anti-phospholipid syndrome (APLS) is a condition characterized by the presence of raised plasma levels of anti-phospholipid antibodies associated with thrombo-embolic disease and/or poor obstetrical outcomes in women. The epidemiology of APLS is unknown in most sub-Saharan African countries due to limited access to diagnosis tools. Case summary We report the case of APLS in a 29-year-old obese woman that was preceded by pre-eclampsia and fetal death. The diagnosis of APLS was made during a thrombo-embolic episode 4 years after the poor obstetrical outcome. Her management was challenging, as she had three thrombo-embolic events within 18-months despite treatment with anti-coagulant (acenocoumarol). Conclusion This case highlights the need for screening for APLS after an episode of hypertensive disease in pregnancy or fetal death, and the challenges faced with the treatment, such as resistance to antivitamin K anti-coagulants and the desire for maternity.http://link.springer.com/article/10.1186/s13104-017-2689-3Anti-phospholipid syndrome (APLS)CameroonSub-Saharan Africa (SSA)Thrombosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ahmadou M. Jingi Liliane Mfeukeu-Kuate Aurel T. Tankeu Narcisse Assene Ateba Edvine Wawo Yonta Jean Jacques Noubiap |
spellingShingle |
Ahmadou M. Jingi Liliane Mfeukeu-Kuate Aurel T. Tankeu Narcisse Assene Ateba Edvine Wawo Yonta Jean Jacques Noubiap Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon BMC Research Notes Anti-phospholipid syndrome (APLS) Cameroon Sub-Saharan Africa (SSA) Thrombosis |
author_facet |
Ahmadou M. Jingi Liliane Mfeukeu-Kuate Aurel T. Tankeu Narcisse Assene Ateba Edvine Wawo Yonta Jean Jacques Noubiap |
author_sort |
Ahmadou M. Jingi |
title |
Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon |
title_short |
Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon |
title_full |
Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon |
title_fullStr |
Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon |
title_full_unstemmed |
Challenges in the diagnosis and management of anti-phospholipid syndrome: a case from Cameroon |
title_sort |
challenges in the diagnosis and management of anti-phospholipid syndrome: a case from cameroon |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2017-08-01 |
description |
Abstract Background Anti-phospholipid syndrome (APLS) is a condition characterized by the presence of raised plasma levels of anti-phospholipid antibodies associated with thrombo-embolic disease and/or poor obstetrical outcomes in women. The epidemiology of APLS is unknown in most sub-Saharan African countries due to limited access to diagnosis tools. Case summary We report the case of APLS in a 29-year-old obese woman that was preceded by pre-eclampsia and fetal death. The diagnosis of APLS was made during a thrombo-embolic episode 4 years after the poor obstetrical outcome. Her management was challenging, as she had three thrombo-embolic events within 18-months despite treatment with anti-coagulant (acenocoumarol). Conclusion This case highlights the need for screening for APLS after an episode of hypertensive disease in pregnancy or fetal death, and the challenges faced with the treatment, such as resistance to antivitamin K anti-coagulants and the desire for maternity. |
topic |
Anti-phospholipid syndrome (APLS) Cameroon Sub-Saharan Africa (SSA) Thrombosis |
url |
http://link.springer.com/article/10.1186/s13104-017-2689-3 |
work_keys_str_mv |
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