Therapeutic perspective of thymoquinone: A mechanistic treatise
Abstract The higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researche...
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doaj-119a236ce3a14e418217eadff6f4253e2021-03-15T12:34:29ZengWileyFood Science & Nutrition2048-71772021-03-01931792180910.1002/fsn3.2070Therapeutic perspective of thymoquinone: A mechanistic treatiseMasood Sadiq Butt0Muhammad Imran1Ali Imran2Muhammad Sajid Arshad3Farhan Saeed4Tanweer Aslam Gondal5Mohammad Ali Shariati6Syed Amir Gilani7Tabussam Tufail8Ishtiaque Ahmad9Nadir Ali Rind10Mohamad Fawzi Mahomoodally11Saiful Islam12Zaffar Mehmood13Faculty of Food, Nutrition & Home Sciences National Institute of Food Science and TechnologyUAF Faisalabad PakistanFaculty of Allied Health Sciences University Institute of Diet and Nutritional SciencesThe University of Lahore Lahore PakistanDepartment of Food Science Institute of Home and Food Sciences Government College University Faisalabad PakistanDepartment of Food Science Institute of Home and Food Sciences Government College University Faisalabad PakistanDepartment of Food Science Institute of Home and Food Sciences Government College University Faisalabad PakistanSchool of Exercise and Nutrition Faculty of Health Deakin University Burwood Vic. AustraliaFood Engineering Department Shakarim State University of Semey Semey KazakhstanFaculty of Allied Health Sciences University Institute of Diet and Nutritional SciencesThe University of Lahore Lahore PakistanFaculty of Allied Health Sciences University Institute of Diet and Nutritional SciencesThe University of Lahore Lahore PakistanDepartment of Dairy Technology University of Veterinary and Animal Sciences Lahore PakistanDepartment of molecular Biology and Genetics Shaheed Benazir Bhutto University Shaheed Benazirabad PakistanDepartment of Health Sciences Faculty of Medicine and Health Sciences University of Mauritius Réduit MauritiusInstitute of Nutrition and Food Science University of Dhaka Dhaka BangladeshSchool of life Sciences Forman Christian College (A Chartered University) Lahore PakistanAbstract The higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researchers due to their pharmacologies perspectives such as prevention from cancer, antidiabetic and antiobesity, prevention from oxidative stress and cardioprotective disorder. Thymoquinone has been found to work as anticancer agent against different human and animal cancer stages including propagation, migration, and invasion. Thymoquinone as phytochemical also downregulated the Rac1 expression, mediated the miR‐34a upregulation, and increased the levels of miR‐34a through p53, as well as also regulated the pro‐ and antiapoptotic genes and decreased the phosphorylation of NF‐κB and IKKα/β. In addition, thymoquinone also lowered the metastasis and ERK1/2 and PI3K activities. The present review article has been piled by adapting narrative review method and highlights the diverse aspects of thymoquinone such as hepatoprotective, anti‐inflammatory, and antiaging through various pathways, and further utilization of this compound in diet has been proven effective against different types of cancers.https://doi.org/10.1002/fsn3.2070anticancerantioxidant potentialcardioprotective disorderphytochemicalthymoquinone |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Masood Sadiq Butt Muhammad Imran Ali Imran Muhammad Sajid Arshad Farhan Saeed Tanweer Aslam Gondal Mohammad Ali Shariati Syed Amir Gilani Tabussam Tufail Ishtiaque Ahmad Nadir Ali Rind Mohamad Fawzi Mahomoodally Saiful Islam Zaffar Mehmood |
spellingShingle |
Masood Sadiq Butt Muhammad Imran Ali Imran Muhammad Sajid Arshad Farhan Saeed Tanweer Aslam Gondal Mohammad Ali Shariati Syed Amir Gilani Tabussam Tufail Ishtiaque Ahmad Nadir Ali Rind Mohamad Fawzi Mahomoodally Saiful Islam Zaffar Mehmood Therapeutic perspective of thymoquinone: A mechanistic treatise Food Science & Nutrition anticancer antioxidant potential cardioprotective disorder phytochemical thymoquinone |
author_facet |
Masood Sadiq Butt Muhammad Imran Ali Imran Muhammad Sajid Arshad Farhan Saeed Tanweer Aslam Gondal Mohammad Ali Shariati Syed Amir Gilani Tabussam Tufail Ishtiaque Ahmad Nadir Ali Rind Mohamad Fawzi Mahomoodally Saiful Islam Zaffar Mehmood |
author_sort |
Masood Sadiq Butt |
title |
Therapeutic perspective of thymoquinone: A mechanistic treatise |
title_short |
Therapeutic perspective of thymoquinone: A mechanistic treatise |
title_full |
Therapeutic perspective of thymoquinone: A mechanistic treatise |
title_fullStr |
Therapeutic perspective of thymoquinone: A mechanistic treatise |
title_full_unstemmed |
Therapeutic perspective of thymoquinone: A mechanistic treatise |
title_sort |
therapeutic perspective of thymoquinone: a mechanistic treatise |
publisher |
Wiley |
series |
Food Science & Nutrition |
issn |
2048-7177 |
publishDate |
2021-03-01 |
description |
Abstract The higher utilization of fruits and vegetables is well known to cure human maladies due to the presence of bioactive components. Among these compounds, thymoquinone, a monoterpene and significant constituent in the essential oil of Nigella sativa L., has attained attention by the researchers due to their pharmacologies perspectives such as prevention from cancer, antidiabetic and antiobesity, prevention from oxidative stress and cardioprotective disorder. Thymoquinone has been found to work as anticancer agent against different human and animal cancer stages including propagation, migration, and invasion. Thymoquinone as phytochemical also downregulated the Rac1 expression, mediated the miR‐34a upregulation, and increased the levels of miR‐34a through p53, as well as also regulated the pro‐ and antiapoptotic genes and decreased the phosphorylation of NF‐κB and IKKα/β. In addition, thymoquinone also lowered the metastasis and ERK1/2 and PI3K activities. The present review article has been piled by adapting narrative review method and highlights the diverse aspects of thymoquinone such as hepatoprotective, anti‐inflammatory, and antiaging through various pathways, and further utilization of this compound in diet has been proven effective against different types of cancers. |
topic |
anticancer antioxidant potential cardioprotective disorder phytochemical thymoquinone |
url |
https://doi.org/10.1002/fsn3.2070 |
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