Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration
Dental pulp as a source of nutrition for the whole tooth is vulnerable to trauma and bacterial invasion, which causes irreversible pulpitis and pulp necrosis. Dental pulp regeneration is a valuable method of restoring the viability of the dental pulp and even the whole tooth. Odontogenic mesenchymal...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-04-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2021.656588/full |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Xiaoyao Huang Xiaoyao Huang Xiaoyao Huang Zihan Li Zihan Li Zihan Li Anqi Liu Anqi Liu Anqi Liu Xuemei Liu Xuemei Liu Xuemei Liu Hao Guo Hao Guo Hao Guo Meiling Wu Meiling Wu Meiling Wu Xiaoxue Yang Xiaoxue Yang Xiaoxue Yang Bing Han Bing Han Bing Han Kun Xuan Kun Xuan Kun Xuan |
| spellingShingle |
Xiaoyao Huang Xiaoyao Huang Xiaoyao Huang Zihan Li Zihan Li Zihan Li Anqi Liu Anqi Liu Anqi Liu Xuemei Liu Xuemei Liu Xuemei Liu Hao Guo Hao Guo Hao Guo Meiling Wu Meiling Wu Meiling Wu Xiaoxue Yang Xiaoxue Yang Xiaoxue Yang Bing Han Bing Han Bing Han Kun Xuan Kun Xuan Kun Xuan Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration Frontiers in Physiology odontogenic MSCs cell aggregate/spheroids dental pulp regeneration microenvironment pulp regeneration approaches |
| author_facet |
Xiaoyao Huang Xiaoyao Huang Xiaoyao Huang Zihan Li Zihan Li Zihan Li Anqi Liu Anqi Liu Anqi Liu Xuemei Liu Xuemei Liu Xuemei Liu Hao Guo Hao Guo Hao Guo Meiling Wu Meiling Wu Meiling Wu Xiaoxue Yang Xiaoxue Yang Xiaoxue Yang Bing Han Bing Han Bing Han Kun Xuan Kun Xuan Kun Xuan |
| author_sort |
Xiaoyao Huang |
| title |
Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration |
| title_short |
Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration |
| title_full |
Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration |
| title_fullStr |
Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration |
| title_full_unstemmed |
Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp Regeneration |
| title_sort |
microenvironment influences odontogenic mesenchymal stem cells mediated dental pulp regeneration |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Physiology |
| issn |
1664-042X |
| publishDate |
2021-04-01 |
| description |
Dental pulp as a source of nutrition for the whole tooth is vulnerable to trauma and bacterial invasion, which causes irreversible pulpitis and pulp necrosis. Dental pulp regeneration is a valuable method of restoring the viability of the dental pulp and even the whole tooth. Odontogenic mesenchymal stem cells (MSCs) residing in the dental pulp environment have been widely used in dental pulp regeneration because of their immense potential to regenerate pulp-like tissue. Furthermore, the regenerative abilities of odontogenic MSCs are easily affected by the microenvironment in which they reside. The natural environment of the dental pulp has been proven to be capable of regulating odontogenic MSC homeostasis, proliferation, and differentiation. Therefore, various approaches have been applied to mimic the natural dental pulp environment to optimize the efficacy of pulp regeneration. In addition, odontogenic MSC aggregates/spheroids similar to the natural dental pulp environment have been shown to regenerate well-organized dental pulp both in preclinical and clinical trials. In this review, we summarize recent progress in odontogenic MSC-mediated pulp regeneration and focus on the effect of the microenvironment surrounding odontogenic MSCs in the achievement of dental pulp regeneration. |
| topic |
odontogenic MSCs cell aggregate/spheroids dental pulp regeneration microenvironment pulp regeneration approaches |
| url |
https://www.frontiersin.org/articles/10.3389/fphys.2021.656588/full |
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1721514967057825792 |
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doaj-119f8ca2f8f74d1fadb9665a612771f12021-04-22T05:34:47ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2021-04-011210.3389/fphys.2021.656588656588Microenvironment Influences Odontogenic Mesenchymal Stem Cells Mediated Dental Pulp RegenerationXiaoyao Huang0Xiaoyao Huang1Xiaoyao Huang2Zihan Li3Zihan Li4Zihan Li5Anqi Liu6Anqi Liu7Anqi Liu8Xuemei Liu9Xuemei Liu10Xuemei Liu11Hao Guo12Hao Guo13Hao Guo14Meiling Wu15Meiling Wu16Meiling Wu17Xiaoxue Yang18Xiaoxue Yang19Xiaoxue Yang20Bing Han21Bing Han22Bing Han23Kun Xuan24Kun Xuan25Kun Xuan26State Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaState Key Laboratory of Military Stomatology, Fourth Military Medical University, Xi’an, ChinaNational Clinical Research Center for Oral Diseases, Fourth Military Medical University, Xi’an, ChinaShaanxi Clinical Research Center for Oral Diseases, Department of Preventive Dentistry, School of Stomatology, Fourth Military Medical University, Xi’an, ChinaDental pulp as a source of nutrition for the whole tooth is vulnerable to trauma and bacterial invasion, which causes irreversible pulpitis and pulp necrosis. Dental pulp regeneration is a valuable method of restoring the viability of the dental pulp and even the whole tooth. Odontogenic mesenchymal stem cells (MSCs) residing in the dental pulp environment have been widely used in dental pulp regeneration because of their immense potential to regenerate pulp-like tissue. Furthermore, the regenerative abilities of odontogenic MSCs are easily affected by the microenvironment in which they reside. The natural environment of the dental pulp has been proven to be capable of regulating odontogenic MSC homeostasis, proliferation, and differentiation. Therefore, various approaches have been applied to mimic the natural dental pulp environment to optimize the efficacy of pulp regeneration. In addition, odontogenic MSC aggregates/spheroids similar to the natural dental pulp environment have been shown to regenerate well-organized dental pulp both in preclinical and clinical trials. In this review, we summarize recent progress in odontogenic MSC-mediated pulp regeneration and focus on the effect of the microenvironment surrounding odontogenic MSCs in the achievement of dental pulp regeneration.https://www.frontiersin.org/articles/10.3389/fphys.2021.656588/fullodontogenic MSCscell aggregate/spheroidsdental pulp regenerationmicroenvironmentpulp regeneration approaches |