Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Inhibition of phosphatidylinositol 3-kinase by PX-866 suppresses temozolomide-induced autophagy and promotes apoptosis in glioblastoma cells

Abstract Background Temozolomide (TMZ) is the most commonly used chemotherapeutic agent used to treat glioblastoma (GBM), which causes significant DNA damage to highly proliferative cells. Our observations have added to accumulating evidence that TMZ induces stress-responsive cellular programs known...

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Bibliographic Details
Main Authors: Bryan G. Harder, Sen Peng, Christopher P. Sereduk, Andrej M. Sodoma, Gaspar J. Kitange, Joseph C. Loftus, Jann N. Sarkaria, Nhan L. Tran
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Molecular Medicine
Subjects:
Glioblastoma (GBM)
Autophagy
Temozolomide (TMZ)
PX-866
PI3K
Bafilomycin
Online Access:http://link.springer.com/article/10.1186/s10020-019-0116-z

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