Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)

Therapeutic drug monitoring of infliximab compared to standard clinical treatment with infliximab: study protocol for a randomised, controlled, open, parallel-group, phase IV study (the NOR-DRUM study)

Abstract Background Infliximab (INX) and other tumour necrosis factor inhibitors (TNFi) have revolutionised the treatment of several immune mediated inflammatory diseases. Still, many patients do not respond sufficiently to therapy or lose efficacy over time. The large interindividual variation in s...

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Bibliographic Details
Main Authors: Silje W Syversen, Guro L Goll, Kristin K Jørgensen, Inge C Olsen, Øystein Sandanger, Johanna E Gehin, David J Warren, Joseph Sexton, Cato Mørk, Jørgen Jahnsen, Tore K Kvien, Nils Bolstad, Espen A Haavardsholm
Format: Article
Language:English
Published: BMC 2020-01-01
Series:Trials
Subjects:
Therapeutic drug monitoring
Infliximab
Immunogenicity
Serum drug levels
Personalised medicine
Online Access:https://doi.org/10.1186/s13063-019-3734-4

Internet

https://doi.org/10.1186/s13063-019-3734-4

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