Beyond the heterodimer model for mineralocorticoid and glucocorticoid receptor interactions in nuclei and at DNA.
Glucocorticoid (GR) and mineralocorticoid receptors (MR) are believed to classically bind DNA as homodimers or MR-GR heterodimers to influence gene regulation in response to pulsatile basal or stress-evoked glucocorticoid secretion. Pulsed corticosterone presentation reveals MR and GR co-occupy DNA...
Main Authors: | John R Pooley, Caroline A Rivers, Michael T Kilcooley, Susana N Paul, Ayse Derya Cavga, Yvonne M Kershaw, Serena Muratcioglu, Attila Gursoy, Ozlem Keskin, Stafford L Lightman |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020-01-01
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Series: | PLoS ONE |
Online Access: | https://doi.org/10.1371/journal.pone.0227520 |
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