Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study
BackgroundLittle is known regarding disease-specific mortality of differentiated thyroid cancer (DTC) patients and its risk factors in Korea.MethodsWe retrospectively reviewed a large multi-center cohort of thyroid cancer from six Korean hospitals and included 8,058 DTC patients who underwent initia...
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Academya Publishing Co.
2017-11-01
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Series: | Endocrinology and Metabolism |
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Online Access: | https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-434.pdf |
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record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Min Ji Jeon Won Gu Kim Tae Hyuk Kim Hee Kyung Kim Bo Hyun Kim Hyon-Seung Yi Eun Sook Kim Hosu Kim Young Nam Kim Eun Heui Kim Tae Yong Kim Sun Wook Kim Ho-Cheol Kang Jae Hoon Chung Young Kee Shong Won Bae Kim |
spellingShingle |
Min Ji Jeon Won Gu Kim Tae Hyuk Kim Hee Kyung Kim Bo Hyun Kim Hyon-Seung Yi Eun Sook Kim Hosu Kim Young Nam Kim Eun Heui Kim Tae Yong Kim Sun Wook Kim Ho-Cheol Kang Jae Hoon Chung Young Kee Shong Won Bae Kim Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study Endocrinology and Metabolism Mortality Risk factors Thyroid neoplasms |
author_facet |
Min Ji Jeon Won Gu Kim Tae Hyuk Kim Hee Kyung Kim Bo Hyun Kim Hyon-Seung Yi Eun Sook Kim Hosu Kim Young Nam Kim Eun Heui Kim Tae Yong Kim Sun Wook Kim Ho-Cheol Kang Jae Hoon Chung Young Kee Shong Won Bae Kim |
author_sort |
Min Ji Jeon |
title |
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study |
title_short |
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study |
title_full |
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study |
title_fullStr |
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study |
title_full_unstemmed |
Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort Study |
title_sort |
disease-specific mortality of differentiated thyroid cancer patients in korea: a multicenter cohort study |
publisher |
Academya Publishing Co. |
series |
Endocrinology and Metabolism |
issn |
2093-596X 2093-5978 |
publishDate |
2017-11-01 |
description |
BackgroundLittle is known regarding disease-specific mortality of differentiated thyroid cancer (DTC) patients and its risk factors in Korea.MethodsWe retrospectively reviewed a large multi-center cohort of thyroid cancer from six Korean hospitals and included 8,058 DTC patients who underwent initial surgery between 1996 and 2005.ResultsMean age of patients at diagnosis was 46.2±12.3 years; 87% were females. Most patients had papillary thyroid cancer (PTC; 97%) and underwent total thyroidectomy (85%). Mean size of the primary tumor was 1.6±1.0 cm. Approximately 40% of patients had cervical lymph node (LN) metastases and 1.3% had synchronous distant metastases. During 11.3 years of follow-up, 150 disease-specific mortalities (1.9%) occurred; the 10-year disease-specific survival (DSS) rate was 98%. According to the year of diagnosis, the number of disease-specific mortality was not different. However, the rate of disease-specific mortality decreased during the study period (from 7.7% to 0.7%). Older age (≥45 years) at diagnosis, male, follicular thyroid cancer (FTC) versus PTC, larger tumor size (>2 cm), presence of extrathyroidal extension (ETE), lateral cervical LN metastasis, distant metastasis and tumor node metastasis (TNM) stage were independent risk factors of disease-specific mortality of DTC patients.ConclusionThe rate of disease-specific mortality of Korean DTC patients was 1.9%; the 10-year DSS rate was 98% during 1996 to 2005. Older age at diagnosis, male, FTC, larger tumor size, presence of ETE, lateral cervical LN metastasis, distant metastasis, and TNM stages were significant risk factors of disease-specific mortality of Korean DTC patients. |
topic |
Mortality Risk factors Thyroid neoplasms |
url |
https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-434.pdf |
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doaj-11c36f3779654a8cbedd260b0d6683fb2020-11-25T01:41:54ZengAcademya Publishing Co.Endocrinology and Metabolism2093-596X2093-59782017-11-0132443444110.3803/EnM.2017.32.4.434Disease-Specific Mortality of Differentiated Thyroid Cancer Patients in Korea: A Multicenter Cohort StudyMin Ji Jeon0Won Gu Kim1Tae Hyuk Kim2Hee Kyung Kim3Bo Hyun Kim4Hyon-Seung Yi5Eun Sook Kim6Hosu Kim7Young Nam Kim8Eun Heui Kim9Tae Yong Kim10Sun Wook Kim11Ho-Cheol Kang12Jae Hoon Chung13Young Kee Shong14Won Bae Kim15Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.Department of Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.BackgroundLittle is known regarding disease-specific mortality of differentiated thyroid cancer (DTC) patients and its risk factors in Korea.MethodsWe retrospectively reviewed a large multi-center cohort of thyroid cancer from six Korean hospitals and included 8,058 DTC patients who underwent initial surgery between 1996 and 2005.ResultsMean age of patients at diagnosis was 46.2±12.3 years; 87% were females. Most patients had papillary thyroid cancer (PTC; 97%) and underwent total thyroidectomy (85%). Mean size of the primary tumor was 1.6±1.0 cm. Approximately 40% of patients had cervical lymph node (LN) metastases and 1.3% had synchronous distant metastases. During 11.3 years of follow-up, 150 disease-specific mortalities (1.9%) occurred; the 10-year disease-specific survival (DSS) rate was 98%. According to the year of diagnosis, the number of disease-specific mortality was not different. However, the rate of disease-specific mortality decreased during the study period (from 7.7% to 0.7%). Older age (≥45 years) at diagnosis, male, follicular thyroid cancer (FTC) versus PTC, larger tumor size (>2 cm), presence of extrathyroidal extension (ETE), lateral cervical LN metastasis, distant metastasis and tumor node metastasis (TNM) stage were independent risk factors of disease-specific mortality of DTC patients.ConclusionThe rate of disease-specific mortality of Korean DTC patients was 1.9%; the 10-year DSS rate was 98% during 1996 to 2005. Older age at diagnosis, male, FTC, larger tumor size, presence of ETE, lateral cervical LN metastasis, distant metastasis, and TNM stages were significant risk factors of disease-specific mortality of Korean DTC patients.https://e-enm.org/Synapse/Data/PDFData/2008ENM/enm-32-434.pdfMortalityRisk factorsThyroid neoplasms |