Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels

Inhibitory Effect of Eslicarbazepine Acetate and S-Licarbazepine on Nav1.5 Channels

Eslicarbazepine acetate (ESL) is a dibenzazepine anticonvulsant approved as adjunctive treatment for partial-onset epileptic seizures. Following first pass hydrolysis of ESL, S-licarbazepine (S-Lic) represents around 95% of circulating active metabolites. S-Lic is the main enantiomer responsible for...

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Bibliographic Details
Main Authors: Theresa K. Leslie, Lotte Brückner, Sangeeta Chawla, William J. Brackenbury
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Pharmacology
Subjects:
anticonvulsant
cancer
epilepsy
eslicarbazepine acetate
Nav1.5
S-licarbazepine
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.555047/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.555047/full

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