Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities
Background: Recent studies identifying methylenetetrahydrofolate reductase (MTHFR) polymorphisms associated with breast cancer (BC), ovarian cancer (OC), cervical cancer, and endometrial cancer (EC) have reported conflicting results and been underpowered. To clarify the correlation between MTHFR mut...
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doaj-11cb5b14a7d045b1a4fe153023055c462021-08-28T04:43:27ZengKeAi Communications Co., Ltd.Chronic Diseases and Translational Medicine2095-882X2021-09-0173169181Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilitiesZheng Wang0Kai Li1Ling Ouyang2Hidasa Iko3Ahmad Javid Safi4Shan Gao5Department of Otorhinolaryngology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaDepartment of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaDepartment of Obstetrics and Gynecology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110001, ChinaJapan Shouko Co. Ltd, Nisikujo 3-5-4 Konohanaku Osakashi Osakafu Japan, 554-0012, JapanAfghanistan Cancer Foundation, Kart-e-Char, Kabul, AfghanistanDepartment of Obstetrics and Gynecology, The Shengjing Hospital of China Medical University, Shenyang, Liaoning 110001, China; Corresponding author. Department of obstetrics and Gynecology, The Shengjing Hospital of China Medical University, No.36, Sanhao Street, Heping District, Shenyang, Liaoning 110001, China.Background: Recent studies identifying methylenetetrahydrofolate reductase (MTHFR) polymorphisms associated with breast cancer (BC), ovarian cancer (OC), cervical cancer, and endometrial cancer (EC) have reported conflicting results and been underpowered. To clarify the correlation between MTHFR mutations and these common female malignancies, we conducted a comprehensive meta-analysis incorporating all eligible publications. Methods: Relevant reports published before January 20, 2020, were retrieved from PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval summaries for the MTHFR 677C/T and 1298A/C polymorphisms in BC, OC, cervical cancer, and EC were estimated. Results: A total of 171 studies comprising 56,675 cancer cases and 67,559 controls were included. The results showed a markedly elevated risk of cancer susceptibility related to MTHFR 677C/T based on all genetic models. Similarly, we identified a significant correlation between 1298A/C mutation and cancer risk based on overall comparisons among all models, except the heterozygous model. Moreover, subgroup analysis by cancer type revealed a significantly increased risk of BC associated with 677C/T in the five models and of cervical cancer associated with 1298A/C in some models. Based on ethnicity, significant associations were observed between Asian, African, and mixed populations for 677C/T and the Asian population for 1298A/C. With regard to the sample type used for analysis, we detected a positive association between using blood as the DNA source and cancer risk for 677C/T in all genetic models and for 1298A/C in some genetic models. Further stratification of the results revealed that a notably increased risk was associated with the use of polymerase chain reaction-restriction fragment-length polymorphism or TaqMan as the genotyping method, as well as with the use of population-or hospital-based groups as the controls for 677C/T and 1298A/C, respectively. Conclusion: This meta-analysis suggests that MTHFR 677C/T and 1298A/C polymorphisms correlate with the risk of common gynecological cancers, with these findings potentially applicable for overall comparisons of related data.http://www.sciencedirect.com/science/article/pii/S2095882X21000463Methylenetetrahydrofolate reductaseBreast cancerFemale genital neoplasmsPolymorphismMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zheng Wang Kai Li Ling Ouyang Hidasa Iko Ahmad Javid Safi Shan Gao |
spellingShingle |
Zheng Wang Kai Li Ling Ouyang Hidasa Iko Ahmad Javid Safi Shan Gao Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities Chronic Diseases and Translational Medicine Methylenetetrahydrofolate reductase Breast cancer Female genital neoplasms Polymorphism Meta-analysis |
author_facet |
Zheng Wang Kai Li Ling Ouyang Hidasa Iko Ahmad Javid Safi Shan Gao |
author_sort |
Zheng Wang |
title |
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities |
title_short |
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities |
title_full |
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities |
title_fullStr |
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities |
title_full_unstemmed |
Effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities |
title_sort |
effects of methylenetetrahydrofolate reductase single-nucleotide polymorphisms on breast, cervical, ovarian, and endometrial cancer susceptibilities |
publisher |
KeAi Communications Co., Ltd. |
series |
Chronic Diseases and Translational Medicine |
issn |
2095-882X |
publishDate |
2021-09-01 |
description |
Background: Recent studies identifying methylenetetrahydrofolate reductase (MTHFR) polymorphisms associated with breast cancer (BC), ovarian cancer (OC), cervical cancer, and endometrial cancer (EC) have reported conflicting results and been underpowered. To clarify the correlation between MTHFR mutations and these common female malignancies, we conducted a comprehensive meta-analysis incorporating all eligible publications. Methods: Relevant reports published before January 20, 2020, were retrieved from PubMed, Embase, the Cochrane Library, and the China National Knowledge Infrastructure databases. The odds ratio and 95% confidence interval summaries for the MTHFR 677C/T and 1298A/C polymorphisms in BC, OC, cervical cancer, and EC were estimated. Results: A total of 171 studies comprising 56,675 cancer cases and 67,559 controls were included. The results showed a markedly elevated risk of cancer susceptibility related to MTHFR 677C/T based on all genetic models. Similarly, we identified a significant correlation between 1298A/C mutation and cancer risk based on overall comparisons among all models, except the heterozygous model. Moreover, subgroup analysis by cancer type revealed a significantly increased risk of BC associated with 677C/T in the five models and of cervical cancer associated with 1298A/C in some models. Based on ethnicity, significant associations were observed between Asian, African, and mixed populations for 677C/T and the Asian population for 1298A/C. With regard to the sample type used for analysis, we detected a positive association between using blood as the DNA source and cancer risk for 677C/T in all genetic models and for 1298A/C in some genetic models. Further stratification of the results revealed that a notably increased risk was associated with the use of polymerase chain reaction-restriction fragment-length polymorphism or TaqMan as the genotyping method, as well as with the use of population-or hospital-based groups as the controls for 677C/T and 1298A/C, respectively. Conclusion: This meta-analysis suggests that MTHFR 677C/T and 1298A/C polymorphisms correlate with the risk of common gynecological cancers, with these findings potentially applicable for overall comparisons of related data. |
topic |
Methylenetetrahydrofolate reductase Breast cancer Female genital neoplasms Polymorphism Meta-analysis |
url |
http://www.sciencedirect.com/science/article/pii/S2095882X21000463 |
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