Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike
As the outermost layer of the body, the skin harbors innumerable and varied microorganisms. These microorganisms interact with the host, and these interactions contribute to host immunity. One of the most abundant genera of skin commensals is <i>Staphylococcus</i>. Bacteria belonging to...
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doaj-11dafa7d15094db38199b0a4e8eca12a2020-11-25T01:51:37ZengMDPI AGInternational Journal of Molecular Sciences1422-00672019-02-0120371810.3390/ijms20030718ijms20030718Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are AlikeYoung Joon Park0Chae Won Kim1Heung Kyu Lee2Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, KoreaBiomedical Science and Engineering Interdisciplinary Program, KAIST, Daejeon 34141, KoreaGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, KoreaAs the outermost layer of the body, the skin harbors innumerable and varied microorganisms. These microorganisms interact with the host, and these interactions contribute to host immunity. One of the most abundant genera of skin commensals is <i>Staphylococcus</i>. Bacteria belonging to this genus are some of the most influential commensals that reside on the skin. For example, colonization by <i>Staphylococcus aureus</i>, a well-known pathogen, increases inflammatory responses within the skin. Conversely, colonization by <i>Staphylococcus epidermis</i>, a coagulase-negative staphylococcal species that are prevalent throughout the skin, can be innocuous or beneficial. Thus, manipulating the abundance of these two bacterial species likely alters the skin microbiome and modulates the cutaneous immune response, with potential implications for various inflammation-associated skin diseases. Importantly, before researchers can begin manipulating the skin microbiome to prevent and treat disease, they must first fully understand how these two species can modulate the cutaneous immune response. In this review, we discuss the nature of the interactions between these two bacterial species and immune cells within the skin, discussing their immunogenicity within the context of skin disorders.https://www.mdpi.com/1422-0067/20/3/718cutaneous immunitymicrobiome<i>Staphylococcus</i> spp., T cells<i>Staphylococcus aureus</i><i>Staphylococcus epidermis</i>commensalsatopic dermatitis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Young Joon Park Chae Won Kim Heung Kyu Lee |
spellingShingle |
Young Joon Park Chae Won Kim Heung Kyu Lee Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike International Journal of Molecular Sciences cutaneous immunity microbiome <i>Staphylococcus</i> spp., T cells <i>Staphylococcus aureus</i> <i>Staphylococcus epidermis</i> commensals atopic dermatitis |
author_facet |
Young Joon Park Chae Won Kim Heung Kyu Lee |
author_sort |
Young Joon Park |
title |
Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike |
title_short |
Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike |
title_full |
Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike |
title_fullStr |
Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike |
title_full_unstemmed |
Interactions between Host Immunity and Skin-Colonizing Staphylococci: No Two Siblings Are Alike |
title_sort |
interactions between host immunity and skin-colonizing staphylococci: no two siblings are alike |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2019-02-01 |
description |
As the outermost layer of the body, the skin harbors innumerable and varied microorganisms. These microorganisms interact with the host, and these interactions contribute to host immunity. One of the most abundant genera of skin commensals is <i>Staphylococcus</i>. Bacteria belonging to this genus are some of the most influential commensals that reside on the skin. For example, colonization by <i>Staphylococcus aureus</i>, a well-known pathogen, increases inflammatory responses within the skin. Conversely, colonization by <i>Staphylococcus epidermis</i>, a coagulase-negative staphylococcal species that are prevalent throughout the skin, can be innocuous or beneficial. Thus, manipulating the abundance of these two bacterial species likely alters the skin microbiome and modulates the cutaneous immune response, with potential implications for various inflammation-associated skin diseases. Importantly, before researchers can begin manipulating the skin microbiome to prevent and treat disease, they must first fully understand how these two species can modulate the cutaneous immune response. In this review, we discuss the nature of the interactions between these two bacterial species and immune cells within the skin, discussing their immunogenicity within the context of skin disorders. |
topic |
cutaneous immunity microbiome <i>Staphylococcus</i> spp., T cells <i>Staphylococcus aureus</i> <i>Staphylococcus epidermis</i> commensals atopic dermatitis |
url |
https://www.mdpi.com/1422-0067/20/3/718 |
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