Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension
Background/Aim. Many studies support the hypothesis that oxidative stress is involved in the pathogenic process of a variety of diseases including hypertension. In humans, hypertension is also considered a state of oxidative stress that can contribute to the development of arteriosclerosis and other...
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Military Health Department, Ministry of Defance, Serbia
2009-01-01
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Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500909695K.pdf |
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doaj-11df1270f3bc4fdbbeeec912c4631a662020-11-24T23:17:17ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502009-01-0166969569910.2298/VSP0909695KImpact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertensionKostić NadaČaparević ZoricaMarina ĐorđeIlić SanjaRadojković JanaĆosić ZoranĆelić VeraPenčić BiljanaRadojković IvanBackground/Aim. Many studies support the hypothesis that oxidative stress is involved in the pathogenic process of a variety of diseases including hypertension. In humans, hypertension is also considered a state of oxidative stress that can contribute to the development of arteriosclerosis and other hypertension- induced organ damage. The aim of this study was to evaluate an influence of acute physical exercise on antioxidative enzymes activity and lipid status in patients with hypertension. Methods. Forty patients with hypertension and 20 age-matched controls were included in the study. To assess an influence of acute exercise on lipids and antioxidative enzymes activity the following parameters were determined at rest and immediately after the acute cardiopulmonary exercise cycloergometer test: triglycerides (TG), total cholesterol, low density cholesterol (LDL), oxidised LDL cholesterol (OxLDL), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and plasminogen activator inhibitor (PAI). Results. In basal condition, hypertensive patients compared to the control group had increased, but not significantly, level of Ox LDL (88.61±14.06 vs 79.00±29.26 mmol/L), PAI (3.06±0.56 vs 2.6±0.35 U/mL) and activity of GSH-Px (50.22±15.20 vs 44.63±13.73 U/g Hb). After acute exercise test, there was significantly greater level of Ox LDL (79.0±29.26 vs 89.3±29.07 mmol/L; p < 0.05) only in the control group. GSH-Px activity was significantly decreased only in hypertensive patients after acute exercise (50.22±15.2 vs 42.82±13.42 U/g Hb; p < 0.05), but not in the controls. Conclusion. No significantly elevated Ox LDL, GSH-Px and PAI-1 levels were found in hypertensive patients during basal condition in comparison with healthy subjects. Decreased GSH-Px activity was associated with those in acute exercise only in hypertensive patients. It could be an important indicator of deficiency of physiological antioxidative defense mechanism in hypertensive patients during an acute exercise.http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500909695K.pdfhypertensionexerciseoxidoreductasestriglyceridescholesterollipoproteinsLDL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kostić Nada Čaparević Zorica Marina Đorđe Ilić Sanja Radojković Jana Ćosić Zoran Ćelić Vera Penčić Biljana Radojković Ivan |
spellingShingle |
Kostić Nada Čaparević Zorica Marina Đorđe Ilić Sanja Radojković Jana Ćosić Zoran Ćelić Vera Penčić Biljana Radojković Ivan Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension Vojnosanitetski Pregled hypertension exercise oxidoreductases triglycerides cholesterol lipoproteins LDL |
author_facet |
Kostić Nada Čaparević Zorica Marina Đorđe Ilić Sanja Radojković Jana Ćosić Zoran Ćelić Vera Penčić Biljana Radojković Ivan |
author_sort |
Kostić Nada |
title |
Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension |
title_short |
Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension |
title_full |
Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension |
title_fullStr |
Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension |
title_full_unstemmed |
Impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension |
title_sort |
impact of acute exercise on antioxidant enzymes activity and lipid status in blood of patients with hypertension |
publisher |
Military Health Department, Ministry of Defance, Serbia |
series |
Vojnosanitetski Pregled |
issn |
0042-8450 |
publishDate |
2009-01-01 |
description |
Background/Aim. Many studies support the hypothesis that oxidative stress is involved in the pathogenic process of a variety of diseases including hypertension. In humans, hypertension is also considered a state of oxidative stress that can contribute to the development of arteriosclerosis and other hypertension- induced organ damage. The aim of this study was to evaluate an influence of acute physical exercise on antioxidative enzymes activity and lipid status in patients with hypertension. Methods. Forty patients with hypertension and 20 age-matched controls were included in the study. To assess an influence of acute exercise on lipids and antioxidative enzymes activity the following parameters were determined at rest and immediately after the acute cardiopulmonary exercise cycloergometer test: triglycerides (TG), total cholesterol, low density cholesterol (LDL), oxidised LDL cholesterol (OxLDL), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and plasminogen activator inhibitor (PAI). Results. In basal condition, hypertensive patients compared to the control group had increased, but not significantly, level of Ox LDL (88.61±14.06 vs 79.00±29.26 mmol/L), PAI (3.06±0.56 vs 2.6±0.35 U/mL) and activity of GSH-Px (50.22±15.20 vs 44.63±13.73 U/g Hb). After acute exercise test, there was significantly greater level of Ox LDL (79.0±29.26 vs 89.3±29.07 mmol/L; p < 0.05) only in the control group. GSH-Px activity was significantly decreased only in hypertensive patients after acute exercise (50.22±15.2 vs 42.82±13.42 U/g Hb; p < 0.05), but not in the controls. Conclusion. No significantly elevated Ox LDL, GSH-Px and PAI-1 levels were found in hypertensive patients during basal condition in comparison with healthy subjects. Decreased GSH-Px activity was associated with those in acute exercise only in hypertensive patients. It could be an important indicator of deficiency of physiological antioxidative defense mechanism in hypertensive patients during an acute exercise. |
topic |
hypertension exercise oxidoreductases triglycerides cholesterol lipoproteins LDL |
url |
http://www.doiserbia.nb.rs/img/doi/0042-8450/2009/0042-84500909695K.pdf |
work_keys_str_mv |
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