Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

Astrocytes have emerged as integral partners with neurons in regulating synapse formation and function, but the mechanisms that mediate these interactions are not well understood. Here, we show that Sonic hedgehog (Shh) signaling in mature astrocytes is required for establishing structural organizat...

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Bibliographic Details
Main Authors: Steven A Hill, Andrew S Blaeser, Austin A Coley, Yajun Xie, Katherine A Shepard, Corey C Harwell, Wen-Jun Gao, A Denise R Garcia
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-06-01
Series:eLife
Subjects:
astrocyte
synapse
Sonic hedgehog
plasticity
development
spines
Online Access:https://elifesciences.org/articles/45545

Internet

https://elifesciences.org/articles/45545

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