The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell
Similar to other cell types, neutrophilic granulocytes also release extracellular vesicles (EVs), mainly medium-sized microvesicles/microparticles. According to published data, authors have reached a consensus on the physical parameters (size, density) and chemical composition (surface proteins, pro...
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doaj-11edbf4a395540648cf54124be1383912020-12-19T00:04:53ZengMDPI AGCells2073-44092020-12-0192718271810.3390/cells9122718The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent CellFerenc Kolonics0Viktória Szeifert1Csaba I. Timár2Erzsébet Ligeti3Ákos M. Lőrincz4Department of Physiology, Semmelweis University, 1085 Budapest, HungaryDepartment of Physiology, Semmelweis University, 1085 Budapest, HungaryDepartment of Physiology, Semmelweis University, 1085 Budapest, HungaryDepartment of Physiology, Semmelweis University, 1085 Budapest, HungaryDepartment of Physiology, Semmelweis University, 1085 Budapest, HungarySimilar to other cell types, neutrophilic granulocytes also release extracellular vesicles (EVs), mainly medium-sized microvesicles/microparticles. According to published data, authors have reached a consensus on the physical parameters (size, density) and chemical composition (surface proteins, proteomics) of neutrophil-derived EVs. In contrast, there is large diversity and even controversy in the reported functional properties. Part of the discrepancy may be ascribed to differences in the viability of the starting cells, in eliciting factors, in separation techniques and in storage conditions. However, the most recent data from our laboratory prove that the same population of neutrophils is able to generate EVs with different functional properties, transmitting pro-inflammatory or anti-inflammatory effects on neighboring cells. Previously we have shown that Mac-1 integrin is a key factor that switches anti-inflammatory EV generation into pro-inflammatory and antibacterial EV production. This paper reviews current knowledge on the functional alterations initiated by neutrophil-derived EVs, listing their effects according to the triggering agents and target cells. We summarize the presence of neutrophil-derived EVs in pathological processes and their perspectives in diagnostics and therapy. Finally, the functional heterogeneity of differently triggered EVs indicates that neutrophils are capable of producing a broad spectrum of EVs, depending on the environmental conditions prevailing at the time of EV genesis.https://www.mdpi.com/2073-4409/9/12/2718extracellular vesiclesmicrovesiclesneutrophilsanti-inflammatory effectspro-inflammatory effectsinflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ferenc Kolonics Viktória Szeifert Csaba I. Timár Erzsébet Ligeti Ákos M. Lőrincz |
spellingShingle |
Ferenc Kolonics Viktória Szeifert Csaba I. Timár Erzsébet Ligeti Ákos M. Lőrincz The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell Cells extracellular vesicles microvesicles neutrophils anti-inflammatory effects pro-inflammatory effects inflammation |
author_facet |
Ferenc Kolonics Viktória Szeifert Csaba I. Timár Erzsébet Ligeti Ákos M. Lőrincz |
author_sort |
Ferenc Kolonics |
title |
The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell |
title_short |
The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell |
title_full |
The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell |
title_fullStr |
The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell |
title_full_unstemmed |
The Functional Heterogeneity of Neutrophil-Derived Extracellular Vesicles Reflects the Status of the Parent Cell |
title_sort |
functional heterogeneity of neutrophil-derived extracellular vesicles reflects the status of the parent cell |
publisher |
MDPI AG |
series |
Cells |
issn |
2073-4409 |
publishDate |
2020-12-01 |
description |
Similar to other cell types, neutrophilic granulocytes also release extracellular vesicles (EVs), mainly medium-sized microvesicles/microparticles. According to published data, authors have reached a consensus on the physical parameters (size, density) and chemical composition (surface proteins, proteomics) of neutrophil-derived EVs. In contrast, there is large diversity and even controversy in the reported functional properties. Part of the discrepancy may be ascribed to differences in the viability of the starting cells, in eliciting factors, in separation techniques and in storage conditions. However, the most recent data from our laboratory prove that the same population of neutrophils is able to generate EVs with different functional properties, transmitting pro-inflammatory or anti-inflammatory effects on neighboring cells. Previously we have shown that Mac-1 integrin is a key factor that switches anti-inflammatory EV generation into pro-inflammatory and antibacterial EV production. This paper reviews current knowledge on the functional alterations initiated by neutrophil-derived EVs, listing their effects according to the triggering agents and target cells. We summarize the presence of neutrophil-derived EVs in pathological processes and their perspectives in diagnostics and therapy. Finally, the functional heterogeneity of differently triggered EVs indicates that neutrophils are capable of producing a broad spectrum of EVs, depending on the environmental conditions prevailing at the time of EV genesis. |
topic |
extracellular vesicles microvesicles neutrophils anti-inflammatory effects pro-inflammatory effects inflammation |
url |
https://www.mdpi.com/2073-4409/9/12/2718 |
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