Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity
Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects,...
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doaj-11efaa22997043188dccb306159a7bba2020-11-25T01:00:58ZengMDPI AGViruses1999-49152015-03-01741613162610.3390/v7041613v7041613Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational ActivitySuhong Qian0Wenchun Fan1Ping Qian2Dong Zhang3Yurong Wei4Huanchun Chen5Xiangmin Li6State Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaState Key Laboratory of Agricultural Microbiology, Laboratory of Animal Virology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan 430070, Hubei, ChinaFoot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studies demonstrate the following: (i) apigenin inhibits FMDV infection at the viral post-entry stage; (ii) apigenin does not exhibit direct extracellular virucidal activity; and (iii) apigenin interferes with the translational activity of FMDV driven by internal ribosome entry site. Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection.http://www.mdpi.com/1999-4915/7/4/1613foot-and-mouth disease virusApigeninAntiviralInternal ribosome entry site |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suhong Qian Wenchun Fan Ping Qian Dong Zhang Yurong Wei Huanchun Chen Xiangmin Li |
spellingShingle |
Suhong Qian Wenchun Fan Ping Qian Dong Zhang Yurong Wei Huanchun Chen Xiangmin Li Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity Viruses foot-and-mouth disease virus Apigenin Antiviral Internal ribosome entry site |
author_facet |
Suhong Qian Wenchun Fan Ping Qian Dong Zhang Yurong Wei Huanchun Chen Xiangmin Li |
author_sort |
Suhong Qian |
title |
Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity |
title_short |
Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity |
title_full |
Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity |
title_fullStr |
Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity |
title_full_unstemmed |
Apigenin Restricts FMDV Infection and Inhibits Viral IRES Driven Translational Activity |
title_sort |
apigenin restricts fmdv infection and inhibits viral ires driven translational activity |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2015-03-01 |
description |
Foot-and-mouth disease (FMD) is a highly contagious disease of domestic and wild ruminants that is caused by FMD virus (FMDV). FMD outbreaks have occurred in livestock-containing regions worldwide. Apigenin, which is a flavonoid naturally existing in plant, possesses various pharmacological effects, including anti-inflammatory, anticancer, antioxidant and antiviral activities. Results show that apigenin can inhibit FMDV-mediated cytopathogenic effect and FMDV replication in vitro. Further studies demonstrate the following: (i) apigenin inhibits FMDV infection at the viral post-entry stage; (ii) apigenin does not exhibit direct extracellular virucidal activity; and (iii) apigenin interferes with the translational activity of FMDV driven by internal ribosome entry site. Studies on applying apigein in vivo are required for drug development and further identification of potential drug targets against FDMV infection. |
topic |
foot-and-mouth disease virus Apigenin Antiviral Internal ribosome entry site |
url |
http://www.mdpi.com/1999-4915/7/4/1613 |
work_keys_str_mv |
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