(<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one

(<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one

A new compound (<i>E</i>)-3-[3-(4-morpholinophenyl)acryloyl]-2<i>H</i>-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde...

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Main Authors: Hery Suwito, Helda Dwi Hardiyanti, Kautsar Ul Haq, Alfinda Novi Kristanti, Miratul Khasanah
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Molbank
Subjects:
molecular hybridization
coumarin-chalcone
anticancer
Online Access:https://www.mdpi.com/1422-8599/2018/4/M1027
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spelling doaj-11f78ad9a66449fd93c199414ba09ba92020-11-24T21:09:31ZengMDPI AGMolbank1422-85992018-10-0120184M102710.3390/M1027M1027(<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-oneHery Suwito0Helda Dwi Hardiyanti1Kautsar Ul Haq2Alfinda Novi Kristanti3Miratul Khasanah4Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, IndonesiaDepartment of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, IndonesiaA new compound (<i>E</i>)-3-[3-(4-morpholinophenyl)acryloyl]-2<i>H</i>-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using <i>p</i>TSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, <sup>1</sup>H- and <sup>13</sup>C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.https://www.mdpi.com/1422-8599/2018/4/M1027molecular hybridizationcoumarin-chalconeanticancer
collection DOAJ
language English
format Article
sources DOAJ
author Hery Suwito
Helda Dwi Hardiyanti
Kautsar Ul Haq
Alfinda Novi Kristanti
Miratul Khasanah
spellingShingle Hery Suwito
Helda Dwi Hardiyanti
Kautsar Ul Haq
Alfinda Novi Kristanti
Miratul Khasanah
(<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one
Molbank
molecular hybridization
coumarin-chalcone
anticancer
author_facet Hery Suwito
Helda Dwi Hardiyanti
Kautsar Ul Haq
Alfinda Novi Kristanti
Miratul Khasanah
author_sort Hery Suwito
title (<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one
title_short (<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one
title_full (<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one
title_fullStr (<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one
title_full_unstemmed (<em>E</em>)-3-[3-(4-Morpholinophenyl)acryloyl]-2<em>H</em>-chromen-2-one
title_sort (<em>e</em>)-3-[3-(4-morpholinophenyl)acryloyl]-2<em>h</em>-chromen-2-one
publisher MDPI AG
series Molbank
issn 1422-8599
publishDate 2018-10-01
description A new compound (<i>E</i>)-3-[3-(4-morpholinophenyl)acryloyl]-2<i>H</i>-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using <i>p</i>TSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, <sup>1</sup>H- and <sup>13</sup>C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
topic molecular hybridization
coumarin-chalcone
anticancer
url https://www.mdpi.com/1422-8599/2018/4/M1027
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AT heldadwihardiyanti emeem334morpholinophenylacryloyl2emhemchromen2one
AT kautsarulhaq emeem334morpholinophenylacryloyl2emhemchromen2one
AT alfindanovikristanti emeem334morpholinophenylacryloyl2emhemchromen2one
AT miratulkhasanah emeem334morpholinophenylacryloyl2emhemchromen2one
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