Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among th...
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doaj-11f962e336eb47f9a0a1fe18a9ee70a82020-11-24T23:17:17ZengMDPI AGViruses1999-49152012-09-01491731175210.3390/v4091731Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape?Roberto BurioniLaura SolforosiMassimo ClementiRoberta A. DiottiMatteo CastelliElena CriscuoloNicola ClementiGiuseppe SauttoMancini NicasioThe immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this “novel” evasion strategy.http://www.mdpi.com/1999-4915/4/9/1731neutralizing antibodiesnon-neutralizing antibodiesinterfering antibodiesviral escape mechanism |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberto Burioni Laura Solforosi Massimo Clementi Roberta A. Diotti Matteo Castelli Elena Criscuolo Nicola Clementi Giuseppe Sautto Mancini Nicasio |
spellingShingle |
Roberto Burioni Laura Solforosi Massimo Clementi Roberta A. Diotti Matteo Castelli Elena Criscuolo Nicola Clementi Giuseppe Sautto Mancini Nicasio Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? Viruses neutralizing antibodies non-neutralizing antibodies interfering antibodies viral escape mechanism |
author_facet |
Roberto Burioni Laura Solforosi Massimo Clementi Roberta A. Diotti Matteo Castelli Elena Criscuolo Nicola Clementi Giuseppe Sautto Mancini Nicasio |
author_sort |
Roberto Burioni |
title |
Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? |
title_short |
Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? |
title_full |
Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? |
title_fullStr |
Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? |
title_full_unstemmed |
Neutralization Interfering Antibodies: A “Novel” Example of Humoral Immune Dysfunction Facilitating Viral Escape? |
title_sort |
neutralization interfering antibodies: a “novel” example of humoral immune dysfunction facilitating viral escape? |
publisher |
MDPI AG |
series |
Viruses |
issn |
1999-4915 |
publishDate |
2012-09-01 |
description |
The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this “novel” evasion strategy. |
topic |
neutralizing antibodies non-neutralizing antibodies interfering antibodies viral escape mechanism |
url |
http://www.mdpi.com/1999-4915/4/9/1731 |
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