Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors
The eye is provided with immune protection against pathogens in a manner that greatly reduces the threat of inflammation-induced vision loss. Immune-mediated inflammation and allograft rejection are greatly reduced in the eye, a phenomenon called ‘immune privilege’. Corneal tissue has inherent immun...
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2020-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/11/3962 |
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doaj-1203dbb7df1c43bfb39063bfb0958a2c2020-11-25T03:06:12ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-05-01213962396210.3390/ijms21113962Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint InhibitorsJunko Hori0Tomoyuki Kunishige1Yuji Nakano2Department of Ophthalmology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Ophthalmology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanDepartment of Ophthalmology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, JapanThe eye is provided with immune protection against pathogens in a manner that greatly reduces the threat of inflammation-induced vision loss. Immune-mediated inflammation and allograft rejection are greatly reduced in the eye, a phenomenon called ‘immune privilege’. Corneal tissue has inherent immune privilege properties with underlying three mechanisms: (1) anatomical, cellular, and molecular barriers in the cornea; (2) an immunosuppressive microenvironment; and (3) tolerance related to regulatory T cells and anterior chamber-associated immune deviation. This review describes the molecular mechanisms of the immunosuppressive microenvironment and regulatory T cells in the cornea that have been elucidated from animal models of ocular inflammation, especially those involving corneal transplantation, it also provides an update on immune checkpoint molecules in corneal and systemic immune regulation, and its relevance for dry eye associated with checkpoint inhibitor therapy.https://www.mdpi.com/1422-0067/21/11/3962immune privilegeimmune checkpointsimmune-related adverse eventsanterior chamber-associated immune deviationregulatory T cellscorneal transplantation |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Junko Hori Tomoyuki Kunishige Yuji Nakano |
| spellingShingle |
Junko Hori Tomoyuki Kunishige Yuji Nakano Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors International Journal of Molecular Sciences immune privilege immune checkpoints immune-related adverse events anterior chamber-associated immune deviation regulatory T cells corneal transplantation |
| author_facet |
Junko Hori Tomoyuki Kunishige Yuji Nakano |
| author_sort |
Junko Hori |
| title |
Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors |
| title_short |
Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors |
| title_full |
Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors |
| title_fullStr |
Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors |
| title_full_unstemmed |
Immune Checkpoints Contribute Corneal Immune Privilege: Implications for Dry Eye Associated with Checkpoint Inhibitors |
| title_sort |
immune checkpoints contribute corneal immune privilege: implications for dry eye associated with checkpoint inhibitors |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1661-6596 1422-0067 |
| publishDate |
2020-05-01 |
| description |
The eye is provided with immune protection against pathogens in a manner that greatly reduces the threat of inflammation-induced vision loss. Immune-mediated inflammation and allograft rejection are greatly reduced in the eye, a phenomenon called ‘immune privilege’. Corneal tissue has inherent immune privilege properties with underlying three mechanisms: (1) anatomical, cellular, and molecular barriers in the cornea; (2) an immunosuppressive microenvironment; and (3) tolerance related to regulatory T cells and anterior chamber-associated immune deviation. This review describes the molecular mechanisms of the immunosuppressive microenvironment and regulatory T cells in the cornea that have been elucidated from animal models of ocular inflammation, especially those involving corneal transplantation, it also provides an update on immune checkpoint molecules in corneal and systemic immune regulation, and its relevance for dry eye associated with checkpoint inhibitor therapy. |
| topic |
immune privilege immune checkpoints immune-related adverse events anterior chamber-associated immune deviation regulatory T cells corneal transplantation |
| url |
https://www.mdpi.com/1422-0067/21/11/3962 |
| work_keys_str_mv |
AT junkohori immunecheckpointscontributecornealimmuneprivilegeimplicationsfordryeyeassociatedwithcheckpointinhibitors AT tomoyukikunishige immunecheckpointscontributecornealimmuneprivilegeimplicationsfordryeyeassociatedwithcheckpointinhibitors AT yujinakano immunecheckpointscontributecornealimmuneprivilegeimplicationsfordryeyeassociatedwithcheckpointinhibitors |
| _version_ |
1724674620479504384 |