In Situ Generated Novel 1H MRI Reporter for β-Galactosidase Activity Detection and Visualization in Living Tumor Cells

In Situ Generated Novel 1H MRI Reporter for β-Galactosidase Activity Detection and Visualization in Living Tumor Cells

For wide applications of the lacZ gene in cellular/molecular biology, small animal investigations, and clinical assessments, the improvement of noninvasive imaging approaches to precisely assay gene expression has garnered much attention. In this study, we investigate a novel molecular platform in w...

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Bibliographic Details
Main Authors:	Shuo Gao, Lei Zhao, Zhiqiang Fan, Vikram D. Kodibagkar, Li Liu, Hanqin Wang, Hong Xu, Mingli Tu, Bifu Hu, Chuanbin Cao, Zhenjian Zhang, Jian-Xin Yu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Chemistry
Subjects:	β-galactosidase detection responsive Fe-based 1H-MRI agent T1 and T2 relaxation mapping in vitro1H-MRI imaging lacZ gene reporter synthesis
Online Access:	https://www.frontiersin.org/articles/10.3389/fchem.2021.709581/full

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