White-matter changes correlate with cognitive functioning in Parkinson's disease
Diffusion tensor imaging (DTI) findings from emerging studies of cortical white-matter integrity in Parkinson’s disease (PD) without dementia are inconclusive. When white-matter changes have been found, their relationship to cognitive functioning in PD has not been carefully investigated. To bette...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2013-04-01
|
Series: | Frontiers in Neurology |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00037/full |
id |
doaj-121d1709332643fd926126a34a3fdc68 |
---|---|
record_format |
Article |
spelling |
doaj-121d1709332643fd926126a34a3fdc682020-11-24T22:16:40ZengFrontiers Media S.A.Frontiers in Neurology1664-22952013-04-01410.3389/fneur.2013.0003747849White-matter changes correlate with cognitive functioning in Parkinson's diseaseRebecca J Theilmann0Jason D Reed1Jason D Reed2David D Song3David D Song4Mingxiong X Huang5Mingxiong X Huang6Roland R Lee7Roland R Lee8Irene eLitvan9Deborah L Harrington10Deborah L Harrington11University of California, San DiegoUniversity of California, San DiegoVA San Diego Healthcare SystemUniversity of California, San DiegoVA San Diego Healthcare SystemUniversity of California, San DiegoVA San Diego Healthcare SystemUniversity of California, San DiegoVA San Diego Healthcare SystemUniversity of California, San DiegoUniversity of California, San DiegoVA San Diego Healthcare SystemDiffusion tensor imaging (DTI) findings from emerging studies of cortical white-matter integrity in Parkinson’s disease (PD) without dementia are inconclusive. When white-matter changes have been found, their relationship to cognitive functioning in PD has not been carefully investigated. To better characterize changes in tissue diffusivity and to understand their functional significance, the present study conducted DTI in 25 PD patients without dementia and 26 controls of similar ages. An automated tract-based DTI method was used. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were analyzed. Neuropsychological measures of executive functioning (working memory, verbal fluency, cognitive flexibility, inhibitory control) and visuospatial ability were then correlated with regions of interest that showed abnormal diffusivity in the PD group. We found widespread reductions in FA and increases in MD in the PD group relative to controls. These changes were predominantly related to an increase in RD. Increased AD in the PD group was limited to specific frontal tracks of the right hemisphere, possibly signifying more significant tissue changes. Motor-symptom severity did not correlate with FA. However, different measures of executive functioning and visuospatial ability correlated with FA in different segments of tracts, which contain fiber pathways to cortical regions that are thought to support specific cognitive processes. The findings suggest that abnormal tissue diffusivity may be sensitive to subtle cognitive changes in PD, some of which may be prognostic of future cognitive decline.http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00037/fullCerebral CortexCognitionDiffusion Tensor ImagingParkinson Diseasewhite matter |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Rebecca J Theilmann Jason D Reed Jason D Reed David D Song David D Song Mingxiong X Huang Mingxiong X Huang Roland R Lee Roland R Lee Irene eLitvan Deborah L Harrington Deborah L Harrington |
spellingShingle |
Rebecca J Theilmann Jason D Reed Jason D Reed David D Song David D Song Mingxiong X Huang Mingxiong X Huang Roland R Lee Roland R Lee Irene eLitvan Deborah L Harrington Deborah L Harrington White-matter changes correlate with cognitive functioning in Parkinson's disease Frontiers in Neurology Cerebral Cortex Cognition Diffusion Tensor Imaging Parkinson Disease white matter |
author_facet |
Rebecca J Theilmann Jason D Reed Jason D Reed David D Song David D Song Mingxiong X Huang Mingxiong X Huang Roland R Lee Roland R Lee Irene eLitvan Deborah L Harrington Deborah L Harrington |
author_sort |
Rebecca J Theilmann |
title |
White-matter changes correlate with cognitive functioning in Parkinson's disease |
title_short |
White-matter changes correlate with cognitive functioning in Parkinson's disease |
title_full |
White-matter changes correlate with cognitive functioning in Parkinson's disease |
title_fullStr |
White-matter changes correlate with cognitive functioning in Parkinson's disease |
title_full_unstemmed |
White-matter changes correlate with cognitive functioning in Parkinson's disease |
title_sort |
white-matter changes correlate with cognitive functioning in parkinson's disease |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neurology |
issn |
1664-2295 |
publishDate |
2013-04-01 |
description |
Diffusion tensor imaging (DTI) findings from emerging studies of cortical white-matter integrity in Parkinson’s disease (PD) without dementia are inconclusive. When white-matter changes have been found, their relationship to cognitive functioning in PD has not been carefully investigated. To better characterize changes in tissue diffusivity and to understand their functional significance, the present study conducted DTI in 25 PD patients without dementia and 26 controls of similar ages. An automated tract-based DTI method was used. Fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were analyzed. Neuropsychological measures of executive functioning (working memory, verbal fluency, cognitive flexibility, inhibitory control) and visuospatial ability were then correlated with regions of interest that showed abnormal diffusivity in the PD group. We found widespread reductions in FA and increases in MD in the PD group relative to controls. These changes were predominantly related to an increase in RD. Increased AD in the PD group was limited to specific frontal tracks of the right hemisphere, possibly signifying more significant tissue changes. Motor-symptom severity did not correlate with FA. However, different measures of executive functioning and visuospatial ability correlated with FA in different segments of tracts, which contain fiber pathways to cortical regions that are thought to support specific cognitive processes. The findings suggest that abnormal tissue diffusivity may be sensitive to subtle cognitive changes in PD, some of which may be prognostic of future cognitive decline. |
topic |
Cerebral Cortex Cognition Diffusion Tensor Imaging Parkinson Disease white matter |
url |
http://journal.frontiersin.org/Journal/10.3389/fneur.2013.00037/full |
work_keys_str_mv |
AT rebeccajtheilmann whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT jasondreed whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT jasondreed whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT daviddsong whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT daviddsong whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT mingxiongxhuang whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT mingxiongxhuang whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT rolandrlee whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT rolandrlee whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT ireneelitvan whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT deborahlharrington whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease AT deborahlharrington whitematterchangescorrelatewithcognitivefunctioninginparkinsonsdisease |
_version_ |
1725788456256274432 |