Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain
In the past few years, new aspects of the immunopathology of Chagas' disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description of the genotypic characterization, at th...
Main Authors: | , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Instituto Oswaldo Cruz, Ministério da Saúde
1998-01-01
|
Series: | Memórias do Instituto Oswaldo Cruz. |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000200005 |
id |
doaj-123e0c5af42f49b397765a77a11c09cf |
---|---|
record_format |
Article |
spelling |
doaj-123e0c5af42f49b397765a77a11c09cf2020-11-24T22:44:22ZengInstituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz.0074-02761678-80601998-01-01932165169Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi StrainPacheco Raquel SFerreira Marcelo SMachado Maria InêsBrito Célia MMPires Marize QDa-Cruz Alda MCoutinho Sérgio GIn the past few years, new aspects of the immunopathology of Chagas' disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description of the genotypic characterization, at the strain level, of Trypanosoma cruzi isolated from a patient with Chagas` disease/AIDS co-infection. The presence of four hypodense lesions was observed in the cranial compute tomographic scan. The diagnosis of AIDS was assessed by the detection of anti-HIV antibodies using enzyme-linked immunosorbent assay (ELISA) and Western blot techniques. The CD4+ lymphocyte counts were maintained under 200 cells/mm3 during one year demonstrating the severity of the state of immunosuppression. Chagas' disease was confirmed by serological and parasitological methods. Trypomastigote forms were visualized in a thick blood smear. The parasite isolated is genotypically similar to the CL strain. The paper reinforces that cerebral Chagas' disease can be considered as another potential opportunistic infection in AIDS resulting from the reactivation of a dormant T. cruzi infection acquired years earlier.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000200005Chagas' disease/AIDS co-infectionopportunistic infectionTrypanosoma cruzireactivation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pacheco Raquel S Ferreira Marcelo S Machado Maria Inês Brito Célia MM Pires Marize Q Da-Cruz Alda M Coutinho Sérgio G |
spellingShingle |
Pacheco Raquel S Ferreira Marcelo S Machado Maria Inês Brito Célia MM Pires Marize Q Da-Cruz Alda M Coutinho Sérgio G Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain Memórias do Instituto Oswaldo Cruz. Chagas' disease/AIDS co-infection opportunistic infection Trypanosoma cruzi reactivation |
author_facet |
Pacheco Raquel S Ferreira Marcelo S Machado Maria Inês Brito Célia MM Pires Marize Q Da-Cruz Alda M Coutinho Sérgio G |
author_sort |
Pacheco Raquel S |
title |
Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_short |
Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_full |
Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_fullStr |
Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_full_unstemmed |
Chagas' Disease and HIV Co-infection: Genotypic Characterization of the Trypanosoma cruzi Strain |
title_sort |
chagas' disease and hiv co-infection: genotypic characterization of the trypanosoma cruzi strain |
publisher |
Instituto Oswaldo Cruz, Ministério da Saúde |
series |
Memórias do Instituto Oswaldo Cruz. |
issn |
0074-0276 1678-8060 |
publishDate |
1998-01-01 |
description |
In the past few years, new aspects of the immunopathology of Chagas' disease have been described in immunosuppressed patients, such as fatal central nervous system lesions related to the reactivation of the parasite. This article is the first description of the genotypic characterization, at the strain level, of Trypanosoma cruzi isolated from a patient with Chagas` disease/AIDS co-infection. The presence of four hypodense lesions was observed in the cranial compute tomographic scan. The diagnosis of AIDS was assessed by the detection of anti-HIV antibodies using enzyme-linked immunosorbent assay (ELISA) and Western blot techniques. The CD4+ lymphocyte counts were maintained under 200 cells/mm3 during one year demonstrating the severity of the state of immunosuppression. Chagas' disease was confirmed by serological and parasitological methods. Trypomastigote forms were visualized in a thick blood smear. The parasite isolated is genotypically similar to the CL strain. The paper reinforces that cerebral Chagas' disease can be considered as another potential opportunistic infection in AIDS resulting from the reactivation of a dormant T. cruzi infection acquired years earlier. |
topic |
Chagas' disease/AIDS co-infection opportunistic infection Trypanosoma cruzi reactivation |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761998000200005 |
work_keys_str_mv |
AT pachecoraquels chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain AT ferreiramarcelos chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain AT machadomariaines chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain AT britoceliamm chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain AT piresmarizeq chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain AT dacruzaldam chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain AT coutinhosergiog chagasdiseaseandhivcoinfectiongenotypiccharacterizationofthetrypanosomacruzistrain |
_version_ |
1725692091723415552 |