Tag-based next generation sequencing: a feasible and reliable assay for EGFR T790M mutation detection in circulating tumor DNA of non small cell lung cancer patients

Tag-based next generation sequencing: a feasible and reliable assay for EGFR T790M mutation detection in circulating tumor DNA of non small cell lung cancer patients

Abstract Background The demonstration of EGFR T790M gene mutation in plasma is crucial to assess the eligibility of Non Small Cell Lung Cancer (NSCLC) patients, who have acquired resistance to first or second generation Tyrosine Kinase Inhibitors (TKIs), to receive a subsequent treatment with osimer...

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Bibliographic Details
Main Authors: Mariella Dono, Giuseppa De Luca, Sonia Lastraioli, Giorgia Anselmi, Maria Giovanna Dal Bello, Simona Coco, Irene Vanni, Francesco Grossi, Antonella Vigani, Carlo Genova, Manlio Ferrarini, Jean Louis Ravetti, Simona Zupo
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Molecular Medicine
Subjects:
Circulating tumor DNA
Liquid biopsy
NSCLC
EGFR TKIs
T790M resistance mutation
Molecular tag
Online Access:http://link.springer.com/article/10.1186/s10020-019-0082-5

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