Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular a...
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Associação Brasileira de Divulgação Científica
2001-01-01
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doaj-123fc55b9ee24e12bdf8682fbfe5ea492020-11-24T23:27:16ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X0034-73102001-01-01345555566Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxinsFierro I.M.Serhan C.N.Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500002inflammationlipoxinsresolution |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Fierro I.M. Serhan C.N. |
spellingShingle |
Fierro I.M. Serhan C.N. Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins Brazilian Journal of Medical and Biological Research inflammation lipoxins resolution |
author_facet |
Fierro I.M. Serhan C.N. |
author_sort |
Fierro I.M. |
title |
Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins |
title_short |
Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins |
title_full |
Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins |
title_fullStr |
Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins |
title_full_unstemmed |
Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins |
title_sort |
mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins |
publisher |
Associação Brasileira de Divulgação Científica |
series |
Brazilian Journal of Medical and Biological Research |
issn |
0100-879X 0034-7310 |
publishDate |
2001-01-01 |
description |
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators. |
topic |
inflammation lipoxins resolution |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500002 |
work_keys_str_mv |
AT fierroim mechanismsinantiinflammationandresolutiontheroleoflipoxinsandaspirintriggeredlipoxins AT serhancn mechanismsinantiinflammationandresolutiontheroleoflipoxinsandaspirintriggeredlipoxins |
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