Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment

Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment

Regulatory T cells (Tregs) are key immunosuppressive cells that promote tumor growth by hindering the effector immune response. Tregs utilize multiple suppressive mechanisms to inhibit pro-inflammatory responses within the tumor microenvironment (TME) by inhibition of effector function and immune ce...

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Bibliographic Details
Main Authors: Ellen N. Scott, Angela M. Gocher, Creg J. Workman, Dario A. A. Vignali
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells (Treg)
immune infiltration
tumor microenvironment
cancer
vasculature
stroma
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.702726/full

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