Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

Skin Aging-Dependent Activation of the PI3K Signaling Pathway via Downregulation of PTEN Increases Intracellular ROS in Human Dermal Fibroblasts

Reactive oxygen species (ROS) play a major role in both chronological aging and photoaging. ROS induce skin aging through their damaging effect on cellular constituents. However, the origins of ROS have not been fully elucidated. We investigated that ROS generation of replicative senescent fibroblas...

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Bibliographic Details
Main Authors:	Eun-Mi Noh, Jinny Park, Hwa-Ryung Song, Jeong-Mi Kim, Minok Lee, Hyun-Kyung Song, On-Yu Hong, Pyoung H. Whang, Myung-Kwan Han, Kang-Beom Kwon, Jong-Suk Kim, Young-Rae Lee
Format:	Article
Language:	English
Published:	Hindawi Limited 2016-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2016/6354261

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