Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient

Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient

A case of cotrimoxazole-induced hypoglycemia is described in a male patient infected with HIV. Ten days after initiating high dose cotrimoxazole for suspected Pneumocystis carinii pneumonia, the patient developed neuroglycopenic symptoms and diaphoresis. Blood glucose levels were repeatedly low, wit...

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Main Authors: Christine A Hughes, Constance L Chik, Geoffrey D Taylor
Format: Article
Language:English
Published: Hindawi Limited 2001-01-01
Series:Canadian Journal of Infectious Diseases
Online Access:http://dx.doi.org/10.1155/2001/848946
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spelling doaj-124e773f3e5e48de9368641de900ab242020-11-25T01:47:09ZengHindawi LimitedCanadian Journal of Infectious Diseases1180-23322001-01-0112531431610.1155/2001/848946Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected PatientChristine A Hughes0Constance L Chik1Geoffrey D Taylor2Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, CanadaDivision of Endocrinology and Metabolism, University of Alberta, Edmonton, Alberta, CanadaDivision of Infectious Diseases, University of Alberta, Edmonton, Alberta, CanadaA case of cotrimoxazole-induced hypoglycemia is described in a male patient infected with HIV. Ten days after initiating high dose cotrimoxazole for suspected Pneumocystis carinii pneumonia, the patient developed neuroglycopenic symptoms and diaphoresis. Blood glucose levels were repeatedly low, with elevated insulin and C-peptide levels despite multiple intravenous bolus doses and infusions of dextrose. Hypoglycemia resolved after approximately 36 h of treatment with dextrose and discontinuation of cotrimoxazole. A review of reported cases of hypoglycemia associated with cotrimoxazole is provided, including information about onset, risk factors and possible mechanism.http://dx.doi.org/10.1155/2001/848946
collection DOAJ
language English
format Article
sources DOAJ
author Christine A Hughes
Constance L Chik
Geoffrey D Taylor
spellingShingle Christine A Hughes
Constance L Chik
Geoffrey D Taylor
Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient
Canadian Journal of Infectious Diseases
author_facet Christine A Hughes
Constance L Chik
Geoffrey D Taylor
author_sort Christine A Hughes
title Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient
title_short Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient
title_full Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient
title_fullStr Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient
title_full_unstemmed Cotrimoxazole-Induced Hypoglycemia in an HIV-Infected Patient
title_sort cotrimoxazole-induced hypoglycemia in an hiv-infected patient
publisher Hindawi Limited
series Canadian Journal of Infectious Diseases
issn 1180-2332
publishDate 2001-01-01
description A case of cotrimoxazole-induced hypoglycemia is described in a male patient infected with HIV. Ten days after initiating high dose cotrimoxazole for suspected Pneumocystis carinii pneumonia, the patient developed neuroglycopenic symptoms and diaphoresis. Blood glucose levels were repeatedly low, with elevated insulin and C-peptide levels despite multiple intravenous bolus doses and infusions of dextrose. Hypoglycemia resolved after approximately 36 h of treatment with dextrose and discontinuation of cotrimoxazole. A review of reported cases of hypoglycemia associated with cotrimoxazole is provided, including information about onset, risk factors and possible mechanism.
url http://dx.doi.org/10.1155/2001/848946
work_keys_str_mv AT christineahughes cotrimoxazoleinducedhypoglycemiainanhivinfectedpatient
AT constancelchik cotrimoxazoleinducedhypoglycemiainanhivinfectedpatient
AT geoffreydtaylor cotrimoxazoleinducedhypoglycemiainanhivinfectedpatient
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