Genetic Complexity of Sinoatrial Node Dysfunction
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is associated with impaired pacemaker function causing...
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doaj-12565219d0e44d409486f3ab9e98b4b42021-04-01T08:07:06ZengFrontiers Media S.A.Frontiers in Genetics1664-80212021-04-011210.3389/fgene.2021.654925654925Genetic Complexity of Sinoatrial Node DysfunctionMichael J. Wallace0Michael J. Wallace1Michael J. Wallace2Mona El Refaey3Mona El Refaey4Mona El Refaey5Pietro Mesirca6Pietro Mesirca7Thomas J. Hund8Thomas J. Hund9Thomas J. Hund10Matteo E. Mangoni11Matteo E. Mangoni12Peter J. Mohler13Peter J. Mohler14Peter J. Mohler15Peter J. Mohler16Frick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesFrick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesCNRS, INSERM, Institut de Génomique Fonctionnelle, Université de Montpellier, Montpellier, FranceLaboratory of Excellence ICST, Montpellier, FranceFrick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus, OH, United StatesCNRS, INSERM, Institut de Génomique Fonctionnelle, Université de Montpellier, Montpellier, FranceLaboratory of Excellence ICST, Montpellier, FranceFrick Center for Heart Failure and Arrhythmia Research, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDepartment of Physiology and Cell Biology, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesDivision of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH, United StatesThe pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is associated with impaired pacemaker function causing abnormal heart rhythm. Individuals with SND have a variety of symptoms including sinus bradycardia, sinus arrest, SAN block, bradycardia/tachycardia syndrome, and syncope. Importantly, individuals with SND report chronotropic incompetence in response to stress and/or exercise. SND may be genetic or secondary to systemic or cardiovascular conditions. Current management of patients with SND is limited to the relief of arrhythmia symptoms and pacemaker implantation if indicated. Lack of effective therapeutic measures that target the underlying causes of SND renders management of these patients challenging due to its progressive nature and has highlighted a critical need to improve our understanding of its underlying mechanistic basis of SND. This review focuses on current information on the genetics underlying SND, followed by future implications of this knowledge in the management of individuals with SND.https://www.frontiersin.org/articles/10.3389/fgene.2021.654925/fullgeneticssick sinus syndromesinoatrial node dysfunctionatrial fibrillationcalsequestrin-2GIRK4 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Michael J. Wallace Michael J. Wallace Michael J. Wallace Mona El Refaey Mona El Refaey Mona El Refaey Pietro Mesirca Pietro Mesirca Thomas J. Hund Thomas J. Hund Thomas J. Hund Matteo E. Mangoni Matteo E. Mangoni Peter J. Mohler Peter J. Mohler Peter J. Mohler Peter J. Mohler |
spellingShingle |
Michael J. Wallace Michael J. Wallace Michael J. Wallace Mona El Refaey Mona El Refaey Mona El Refaey Pietro Mesirca Pietro Mesirca Thomas J. Hund Thomas J. Hund Thomas J. Hund Matteo E. Mangoni Matteo E. Mangoni Peter J. Mohler Peter J. Mohler Peter J. Mohler Peter J. Mohler Genetic Complexity of Sinoatrial Node Dysfunction Frontiers in Genetics genetics sick sinus syndrome sinoatrial node dysfunction atrial fibrillation calsequestrin-2 GIRK4 |
author_facet |
Michael J. Wallace Michael J. Wallace Michael J. Wallace Mona El Refaey Mona El Refaey Mona El Refaey Pietro Mesirca Pietro Mesirca Thomas J. Hund Thomas J. Hund Thomas J. Hund Matteo E. Mangoni Matteo E. Mangoni Peter J. Mohler Peter J. Mohler Peter J. Mohler Peter J. Mohler |
author_sort |
Michael J. Wallace |
title |
Genetic Complexity of Sinoatrial Node Dysfunction |
title_short |
Genetic Complexity of Sinoatrial Node Dysfunction |
title_full |
Genetic Complexity of Sinoatrial Node Dysfunction |
title_fullStr |
Genetic Complexity of Sinoatrial Node Dysfunction |
title_full_unstemmed |
Genetic Complexity of Sinoatrial Node Dysfunction |
title_sort |
genetic complexity of sinoatrial node dysfunction |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Genetics |
issn |
1664-8021 |
publishDate |
2021-04-01 |
description |
The pacemaker cells of the cardiac sinoatrial node (SAN) are essential for normal cardiac automaticity. Dysfunction in cardiac pacemaking results in human sinoatrial node dysfunction (SND). SND more generally occurs in the elderly population and is associated with impaired pacemaker function causing abnormal heart rhythm. Individuals with SND have a variety of symptoms including sinus bradycardia, sinus arrest, SAN block, bradycardia/tachycardia syndrome, and syncope. Importantly, individuals with SND report chronotropic incompetence in response to stress and/or exercise. SND may be genetic or secondary to systemic or cardiovascular conditions. Current management of patients with SND is limited to the relief of arrhythmia symptoms and pacemaker implantation if indicated. Lack of effective therapeutic measures that target the underlying causes of SND renders management of these patients challenging due to its progressive nature and has highlighted a critical need to improve our understanding of its underlying mechanistic basis of SND. This review focuses on current information on the genetics underlying SND, followed by future implications of this knowledge in the management of individuals with SND. |
topic |
genetics sick sinus syndrome sinoatrial node dysfunction atrial fibrillation calsequestrin-2 GIRK4 |
url |
https://www.frontiersin.org/articles/10.3389/fgene.2021.654925/full |
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