mTOR Cross-Talk in Cancer and Potential for Combination Therapy

mTOR Cross-Talk in Cancer and Potential for Combination Therapy

The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions. mTOR functions through two functionally and structurally distinct multi-compo...

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Bibliographic Details
Main Authors: Fabiana Conciatori, Ludovica Ciuffreda, Chiara Bazzichetto, Italia Falcone, Sara Pilotto, Emilio Bria, Francesco Cognetti, Michele Milella
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:Cancers
Subjects:
mTORC1
mTORC2
cancer
cross-talk
targeted therapies
Online Access:http://www.mdpi.com/2072-6694/10/1/23

Internet

http://www.mdpi.com/2072-6694/10/1/23

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