Sestrins are evolutionarily conserved mediators of exercise benefits
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2020-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13442-5 |
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doaj-126b3fa1af5449268749287ab60d04c02021-05-11T09:16:56ZengNature Publishing GroupNature Communications2041-17232020-01-0111111410.1038/s41467-019-13442-5Sestrins are evolutionarily conserved mediators of exercise benefitsMyungjin Kim0Alyson Sujkowski1Sim Namkoong2Bondong Gu3Tyler Cobb4Boyoung Kim5Allison H. Kowalsky6Chun-Seok Cho7Ian Semple8Seung-Hyun Ro9Carol Davis10Susan V. Brooks11Michael Karin12Robert J. Wessells13Jun Hee Lee14Department of Molecular & Integrative Physiology, University of MichiganDepartment of Physiology, Wayne State University School of MedicineDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Physiology, Wayne State University School of MedicineDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Molecular & Integrative Physiology, University of MichiganDepartment of Pharmacology, University of California San DiegoDepartment of Physiology, Wayne State University School of MedicineDepartment of Molecular & Integrative Physiology, University of MichiganExercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.https://doi.org/10.1038/s41467-019-13442-5 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Myungjin Kim Alyson Sujkowski Sim Namkoong Bondong Gu Tyler Cobb Boyoung Kim Allison H. Kowalsky Chun-Seok Cho Ian Semple Seung-Hyun Ro Carol Davis Susan V. Brooks Michael Karin Robert J. Wessells Jun Hee Lee |
| spellingShingle |
Myungjin Kim Alyson Sujkowski Sim Namkoong Bondong Gu Tyler Cobb Boyoung Kim Allison H. Kowalsky Chun-Seok Cho Ian Semple Seung-Hyun Ro Carol Davis Susan V. Brooks Michael Karin Robert J. Wessells Jun Hee Lee Sestrins are evolutionarily conserved mediators of exercise benefits Nature Communications |
| author_facet |
Myungjin Kim Alyson Sujkowski Sim Namkoong Bondong Gu Tyler Cobb Boyoung Kim Allison H. Kowalsky Chun-Seok Cho Ian Semple Seung-Hyun Ro Carol Davis Susan V. Brooks Michael Karin Robert J. Wessells Jun Hee Lee |
| author_sort |
Myungjin Kim |
| title |
Sestrins are evolutionarily conserved mediators of exercise benefits |
| title_short |
Sestrins are evolutionarily conserved mediators of exercise benefits |
| title_full |
Sestrins are evolutionarily conserved mediators of exercise benefits |
| title_fullStr |
Sestrins are evolutionarily conserved mediators of exercise benefits |
| title_full_unstemmed |
Sestrins are evolutionarily conserved mediators of exercise benefits |
| title_sort |
sestrins are evolutionarily conserved mediators of exercise benefits |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-01-01 |
| description |
Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes. |
| url |
https://doi.org/10.1038/s41467-019-13442-5 |
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