NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons

NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons

Neuronal Ca2+ sensor proteins (NCS) transduce changes in Ca2+ homeostasis into altered signaling and neuronal function. NCS-1 activity has emerged as important for neuronal viability and pathophysiology. The progressive degeneration of dopaminergic (DA) neurons, particularly within the Substantia ni...

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Bibliographic Details
Main Authors: Carsten Simons, Julia Benkert, Nora Deuter, Christina Poetschke, Olaf Pongs, Toni Schneider, Johanna Duda, Birgit Liss
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ND1
ENO2
Parkinson’s disease
mitochondrial uncoupling proteins
voltage-gated calcium channels
Cav2.3
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2019.00252/full

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