Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients
We determined the specific activities of some enzymatic antioxidant defenses like superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as a lipid peroxidation marker (MDA-malondialdehyde) from the serum of patients with schizophrenia treated with typical and atypical antipsychotics,...
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"Alexandru Ioan Cuza" University of Iași
2010-12-01
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Series: | Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
Online Access: | http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/822 |
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doaj-1275bb1d8a0a4f9a83e207c461b396852020-11-25T00:51:35Zeng"Alexandru Ioan Cuza" University of IașiAnalele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara 1582-35712248-32762010-12-01114815Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patientsIrina DobrinAlin CiobicaManuela PadurariuBogdan StoicaCristinel StefanescuRoxana ChiritaWe determined the specific activities of some enzymatic antioxidant defenses like superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as a lipid peroxidation marker (MDA-malondialdehyde) from the serum of patients with schizophrenia treated with typical and atypical antipsychotics, in comparison with a normal age- matched control group. We observed an increased oxidative stress in schizophrenic patients treated with typical antipsychotics, compared to controls. Moreover, we demonstrated an antioxidant effect of atypical antipsychotics, since these patients showed an increased activity of SOD, compared to control subjects and a slightly decrease of MDAhttp://www.gbm.bio.uaic.ro/index.php/gbm/article/view/822 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Irina Dobrin Alin Ciobica Manuela Padurariu Bogdan Stoica Cristinel Stefanescu Roxana Chirita |
spellingShingle |
Irina Dobrin Alin Ciobica Manuela Padurariu Bogdan Stoica Cristinel Stefanescu Roxana Chirita Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
author_facet |
Irina Dobrin Alin Ciobica Manuela Padurariu Bogdan Stoica Cristinel Stefanescu Roxana Chirita |
author_sort |
Irina Dobrin |
title |
Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients |
title_short |
Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients |
title_full |
Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients |
title_fullStr |
Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients |
title_full_unstemmed |
Comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients |
title_sort |
comparison between the effects of typical and atypical antipsychotics on oxidative stress status in schizophrenic patients |
publisher |
"Alexandru Ioan Cuza" University of Iași |
series |
Analele Ştiinţifice Ale Universităţii Alexandru Ioan Cuza din Iași,Sectiunea II A : Genetica si Biologie Moleculara |
issn |
1582-3571 2248-3276 |
publishDate |
2010-12-01 |
description |
We determined the specific activities of some enzymatic antioxidant defenses like superoxide dismutase
(SOD) and glutathione peroxidase (GPX), as well as a lipid peroxidation marker (MDA-malondialdehyde) from the
serum of patients with schizophrenia treated with typical and atypical antipsychotics, in comparison with a normal age-
matched control group. We observed an increased oxidative stress in schizophrenic patients treated with typical
antipsychotics, compared to controls. Moreover, we demonstrated an antioxidant effect of atypical antipsychotics, since
these patients showed an increased activity of SOD, compared to control subjects and a slightly decrease of MDA |
url |
http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/822 |
work_keys_str_mv |
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