Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis
Colorectal cancer (CRC) represents one of the most common malignancies with high morbidity worldwide. RNA methylation (m6A) has been considered to tremendously contribute to cancer initiation and progression since its first discovery. In this study, we comprehensively analyzed associations between m...
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2020-05-01
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doaj-127a0de6f792424b8c42d8d6f5dbc31d2020-11-25T02:20:13ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-05-011010.3389/fonc.2020.00768517618Exploration of Potential Roles of m6A Regulators in Colorectal Cancer PrognosisLiechen JiShuo ChenLiqiang GuXipeng ZhangColorectal cancer (CRC) represents one of the most common malignancies with high morbidity worldwide. RNA methylation (m6A) has been considered to tremendously contribute to cancer initiation and progression since its first discovery. In this study, we comprehensively analyzed associations between mRNA expressions of m6A regulators and CRC tumor samples' epidemiologic information from the Cancer Genome Atlas (TCGA). Multivariate Cox proportional hazard model was applied to screening of m6A regulators whose mRNA expressions were significantly associated with CRC tumor samples' overall survival (OS) probability and those significant regulators were used for LASSO regression analysis to construct CRC prognosis prediction signature. As a result, two regulators i.e., YTHDC2 and ALKBH5 were picked out in multivariate analysis. CRC prognosis signature was constructed based on those two regulators through which CRC tumor samples with favorable and inferior prognosis could definitely be distinguished independent of potential confounding factors. This study should be helpful for identifying prognostic different CRC patients and guiding therapeutic method selection.https://www.frontiersin.org/article/10.3389/fonc.2020.00768/fullcolorectal cancerm6Am6A regulatorsprognosisTCGA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Liechen Ji Shuo Chen Liqiang Gu Xipeng Zhang |
spellingShingle |
Liechen Ji Shuo Chen Liqiang Gu Xipeng Zhang Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis Frontiers in Oncology colorectal cancer m6A m6A regulators prognosis TCGA |
author_facet |
Liechen Ji Shuo Chen Liqiang Gu Xipeng Zhang |
author_sort |
Liechen Ji |
title |
Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis |
title_short |
Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis |
title_full |
Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis |
title_fullStr |
Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis |
title_full_unstemmed |
Exploration of Potential Roles of m6A Regulators in Colorectal Cancer Prognosis |
title_sort |
exploration of potential roles of m6a regulators in colorectal cancer prognosis |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Oncology |
issn |
2234-943X |
publishDate |
2020-05-01 |
description |
Colorectal cancer (CRC) represents one of the most common malignancies with high morbidity worldwide. RNA methylation (m6A) has been considered to tremendously contribute to cancer initiation and progression since its first discovery. In this study, we comprehensively analyzed associations between mRNA expressions of m6A regulators and CRC tumor samples' epidemiologic information from the Cancer Genome Atlas (TCGA). Multivariate Cox proportional hazard model was applied to screening of m6A regulators whose mRNA expressions were significantly associated with CRC tumor samples' overall survival (OS) probability and those significant regulators were used for LASSO regression analysis to construct CRC prognosis prediction signature. As a result, two regulators i.e., YTHDC2 and ALKBH5 were picked out in multivariate analysis. CRC prognosis signature was constructed based on those two regulators through which CRC tumor samples with favorable and inferior prognosis could definitely be distinguished independent of potential confounding factors. This study should be helpful for identifying prognostic different CRC patients and guiding therapeutic method selection. |
topic |
colorectal cancer m6A m6A regulators prognosis TCGA |
url |
https://www.frontiersin.org/article/10.3389/fonc.2020.00768/full |
work_keys_str_mv |
AT liechenji explorationofpotentialrolesofm6aregulatorsincolorectalcancerprognosis AT shuochen explorationofpotentialrolesofm6aregulatorsincolorectalcancerprognosis AT liqianggu explorationofpotentialrolesofm6aregulatorsincolorectalcancerprognosis AT xipengzhang explorationofpotentialrolesofm6aregulatorsincolorectalcancerprognosis |
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1724872941596835840 |