Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice
Gynecologic cancers are an important cause of worldwide mortality. The interstitium consists of solid and fluid phases, situated between the blood vessels and cells. The interstitial fluid (IF), or fluid phase, is an extracellular fluid bathing and surrounding the tissue cells. The TIF (tumor inters...
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doaj-127acd33cec145a681f0f8f640ca1c9b2020-11-24T20:44:54ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-12-011912401810.3390/ijms19124018ijms19124018Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical PracticeBlendi Ura0Giovanni Di Lorenzo1Federico Romano2Lorenzo Monasta3Giuseppe Mirenda4Federica Scrimin5Giuseppe Ricci6Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyInstitute for Maternal and Child Health—IRCCS “Burlo Garofolo”, 34137 Trieste, ItalyGynecologic cancers are an important cause of worldwide mortality. The interstitium consists of solid and fluid phases, situated between the blood vessels and cells. The interstitial fluid (IF), or fluid phase, is an extracellular fluid bathing and surrounding the tissue cells. The TIF (tumor interstitial fluid) is a dynamic fluid rich in lipids, proteins and enzyme-derived substances. The molecules found in the IF may be associated with pathological changes in tissues leading to cancer growth and metastatization. Proteomic techniques have allowed an extensive study of the composition of the TIF as a source of biomarkers for gynecologic cancers. In our review, we analyze the composition of the TIF, its formation process, the sampling methods, the consequences of its accumulation and the proteomic analyses performed, that make TIF valuable for monitoring different types of cancers.https://www.mdpi.com/1422-0067/19/12/4018tumor interstitial fluidgynecologic tumorsproteomicsbiomarker |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Blendi Ura Giovanni Di Lorenzo Federico Romano Lorenzo Monasta Giuseppe Mirenda Federica Scrimin Giuseppe Ricci |
spellingShingle |
Blendi Ura Giovanni Di Lorenzo Federico Romano Lorenzo Monasta Giuseppe Mirenda Federica Scrimin Giuseppe Ricci Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice International Journal of Molecular Sciences tumor interstitial fluid gynecologic tumors proteomics biomarker |
author_facet |
Blendi Ura Giovanni Di Lorenzo Federico Romano Lorenzo Monasta Giuseppe Mirenda Federica Scrimin Giuseppe Ricci |
author_sort |
Blendi Ura |
title |
Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice |
title_short |
Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice |
title_full |
Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice |
title_fullStr |
Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice |
title_full_unstemmed |
Interstitial Fluid in Gynecologic Tumors and Its Possible Application in the Clinical Practice |
title_sort |
interstitial fluid in gynecologic tumors and its possible application in the clinical practice |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1422-0067 |
publishDate |
2018-12-01 |
description |
Gynecologic cancers are an important cause of worldwide mortality. The interstitium consists of solid and fluid phases, situated between the blood vessels and cells. The interstitial fluid (IF), or fluid phase, is an extracellular fluid bathing and surrounding the tissue cells. The TIF (tumor interstitial fluid) is a dynamic fluid rich in lipids, proteins and enzyme-derived substances. The molecules found in the IF may be associated with pathological changes in tissues leading to cancer growth and metastatization. Proteomic techniques have allowed an extensive study of the composition of the TIF as a source of biomarkers for gynecologic cancers. In our review, we analyze the composition of the TIF, its formation process, the sampling methods, the consequences of its accumulation and the proteomic analyses performed, that make TIF valuable for monitoring different types of cancers. |
topic |
tumor interstitial fluid gynecologic tumors proteomics biomarker |
url |
https://www.mdpi.com/1422-0067/19/12/4018 |
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