Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder
The global COVID-19 pandemic has brought respiratory disease to the forefront of public health, but asthma prevalence has been rising globally for decades. Asthma is mediated by errant immune activation and airway remodeling, but the influences of environment, nutrition, and comorbidities (e.g., ast...
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doaj-12864879534846a7ad32a2eb54fc983a2021-09-09T13:37:59ZengMDPI AGAllergies2313-57862021-04-01179210710.3390/allergies1020007Biologic Treatments for Asthma and Chronic Obstructive Pulmonary DisorderMisa Kusumoto0Bryan J. Mathis1University of Tsukuba School of Medicine, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, JapanInternational Medical Center, University of Tsukuba Affiliated Hospital, 2-1-1 Amakubo, Tsukuba, Ibaraki 305-8576, JapanThe global COVID-19 pandemic has brought respiratory disease to the forefront of public health, but asthma prevalence has been rising globally for decades. Asthma is mediated by errant immune activation and airway remodeling, but the influences of environment, nutrition, and comorbidities (e.g., asthma-chronic obstructive pulmonary disorder-overlap [ACO]) are still poorly understood. Even as a new generation of biologic-based treatments offer better airway control and reductions in mortality, a lack of prophylactic treatments and mechanistic understanding complicates efforts to prevent pathogenesis. This review will explicate and synthesize current knowledge on the effect of ACO and biologics (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) on pathogenesis, treatment, and prognosis.https://www.mdpi.com/2313-5786/1/2/7asthmaprevalencebiologicACOIL-5 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Misa Kusumoto Bryan J. Mathis |
spellingShingle |
Misa Kusumoto Bryan J. Mathis Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder Allergies asthma prevalence biologic ACO IL-5 |
author_facet |
Misa Kusumoto Bryan J. Mathis |
author_sort |
Misa Kusumoto |
title |
Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder |
title_short |
Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder |
title_full |
Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder |
title_fullStr |
Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder |
title_full_unstemmed |
Biologic Treatments for Asthma and Chronic Obstructive Pulmonary Disorder |
title_sort |
biologic treatments for asthma and chronic obstructive pulmonary disorder |
publisher |
MDPI AG |
series |
Allergies |
issn |
2313-5786 |
publishDate |
2021-04-01 |
description |
The global COVID-19 pandemic has brought respiratory disease to the forefront of public health, but asthma prevalence has been rising globally for decades. Asthma is mediated by errant immune activation and airway remodeling, but the influences of environment, nutrition, and comorbidities (e.g., asthma-chronic obstructive pulmonary disorder-overlap [ACO]) are still poorly understood. Even as a new generation of biologic-based treatments offer better airway control and reductions in mortality, a lack of prophylactic treatments and mechanistic understanding complicates efforts to prevent pathogenesis. This review will explicate and synthesize current knowledge on the effect of ACO and biologics (omalizumab, mepolizumab, reslizumab, benralizumab, and dupilumab) on pathogenesis, treatment, and prognosis. |
topic |
asthma prevalence biologic ACO IL-5 |
url |
https://www.mdpi.com/2313-5786/1/2/7 |
work_keys_str_mv |
AT misakusumoto biologictreatmentsforasthmaandchronicobstructivepulmonarydisorder AT bryanjmathis biologictreatmentsforasthmaandchronicobstructivepulmonarydisorder |
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