Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely...

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Main Authors:	Marissa A. Scavuzzo, Matthew C. Hill, Jolanta Chmielowiec, Diane Yang, Jessica Teaw, Kuanwei Sheng, Yuelin Kong, Maria Bettini, Chenghang Zong, James F. Martin, Malgorzata Borowiak
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-08-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-018-05740-1

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spelling	doaj-128732b885f1499aabecf3b2fb56b5222021-05-11T10:31:28ZengNature Publishing GroupNature Communications2041-17232018-08-019112110.1038/s41467-018-05740-1Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesisMarissa A. Scavuzzo0Matthew C. Hill1Jolanta Chmielowiec2Diane Yang3Jessica Teaw4Kuanwei Sheng5Yuelin Kong6Maria Bettini7Chenghang Zong8James F. Martin9Malgorzata Borowiak10Program in Developmental Biology, Baylor College of MedicineProgram in Developmental Biology, Baylor College of MedicineCenter for Cell and Gene Therapy, Texas Children’s Hospital, and Houston Methodist Hospital, Baylor College of MedicineMolecular and Cellular Biology Department, Baylor College of MedicineCenter for Cell and Gene Therapy, Texas Children’s Hospital, and Houston Methodist Hospital, Baylor College of MedicineIntegrative Molecular and Biomedical Sciences Graduate Program, Baylor College of MedicineDepartment of Pediatrics, Section of Diabetes and Endocrinology, Texas Children’s Hospital, Baylor College of MedicineDepartment of Pediatrics, Section of Diabetes and Endocrinology, Texas Children’s Hospital, Baylor College of MedicineDepartment of Molecular and Human Genetics, Baylor College of MedicineProgram in Developmental Biology, Baylor College of MedicineProgram in Developmental Biology, Baylor College of MedicineEndocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cellshttps://doi.org/10.1038/s41467-018-05740-1
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marissa A. Scavuzzo Matthew C. Hill Jolanta Chmielowiec Diane Yang Jessica Teaw Kuanwei Sheng Yuelin Kong Maria Bettini Chenghang Zong James F. Martin Malgorzata Borowiak
spellingShingle	Marissa A. Scavuzzo Matthew C. Hill Jolanta Chmielowiec Diane Yang Jessica Teaw Kuanwei Sheng Yuelin Kong Maria Bettini Chenghang Zong James F. Martin Malgorzata Borowiak Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis Nature Communications
author_facet	Marissa A. Scavuzzo Matthew C. Hill Jolanta Chmielowiec Diane Yang Jessica Teaw Kuanwei Sheng Yuelin Kong Maria Bettini Chenghang Zong James F. Martin Malgorzata Borowiak
author_sort	Marissa A. Scavuzzo
title	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_short	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_full	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_fullStr	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_full_unstemmed	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_sort	endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2018-08-01
description	Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cells
url	https://doi.org/10.1038/s41467-018-05740-1
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Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

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