Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer
Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and clinicians, including pathologists, to include coll...
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doaj-128d3bc322004035aced146320d9138e2021-01-22T00:01:26ZengMDPI AGBioengineering2306-53542021-01-018171710.3390/bioengineering8020017Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in CancerJonathan N. Ouellette0Cole R. Drifka1Kelli B. Pointer2Yuming Liu3Tyler J Lieberthal4W John Kao5John S. Kuo6Agnes G. Loeffler7Kevin W. Eliceiri8Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USALaboratory for Optical and Computational Instrumentation, Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI 53706, USALaboratory for Optical and Computational Instrumentation, Center for Quantitative Cell Imaging, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USADepartment of Neurosurgery, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USADepartment of Pathology, MetroHealth Medical Center, Cleveland, OH 44109, USADepartment of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USARecent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and clinicians, including pathologists, to include collagen fiber evaluation as part of the investigation of cancer development and progression. Fibrillar collagen is the most abundant in the normal extracellular matrix, and was revealed to be upregulated in many cancers. Recent studies suggested an emerging theme across multiple cancer types in which specific collagen fiber organization patterns differ between benign and malignant tissue and also appear to be associated with disease stage, prognosis, treatment response, and other clinical features. There is great potential for developing image-based collagen fiber biomarkers for clinical applications, but its adoption in standard clinical practice is dependent on further translational and clinical evaluations. Here, we offer a comprehensive review of the current literature of fibrillar collagen structure and organization as a candidate cancer biomarker, and new perspectives on the challenges and next steps for researchers and clinicians seeking to exploit this information in biomedical research and clinical workflows.https://www.mdpi.com/2306-5354/8/2/17fibrillar collagencancerprognosistumor microenvironmentextracellular matrixECM |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jonathan N. Ouellette Cole R. Drifka Kelli B. Pointer Yuming Liu Tyler J Lieberthal W John Kao John S. Kuo Agnes G. Loeffler Kevin W. Eliceiri |
spellingShingle |
Jonathan N. Ouellette Cole R. Drifka Kelli B. Pointer Yuming Liu Tyler J Lieberthal W John Kao John S. Kuo Agnes G. Loeffler Kevin W. Eliceiri Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer Bioengineering fibrillar collagen cancer prognosis tumor microenvironment extracellular matrix ECM |
author_facet |
Jonathan N. Ouellette Cole R. Drifka Kelli B. Pointer Yuming Liu Tyler J Lieberthal W John Kao John S. Kuo Agnes G. Loeffler Kevin W. Eliceiri |
author_sort |
Jonathan N. Ouellette |
title |
Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer |
title_short |
Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer |
title_full |
Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer |
title_fullStr |
Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer |
title_full_unstemmed |
Navigating the Collagen Jungle: The Biomedical Potential of Fiber Organization in Cancer |
title_sort |
navigating the collagen jungle: the biomedical potential of fiber organization in cancer |
publisher |
MDPI AG |
series |
Bioengineering |
issn |
2306-5354 |
publishDate |
2021-01-01 |
description |
Recent research has highlighted the importance of key tumor microenvironment features, notably the collagen-rich extracellular matrix (ECM) in characterizing tumor invasion and progression. This led to great interest from both basic researchers and clinicians, including pathologists, to include collagen fiber evaluation as part of the investigation of cancer development and progression. Fibrillar collagen is the most abundant in the normal extracellular matrix, and was revealed to be upregulated in many cancers. Recent studies suggested an emerging theme across multiple cancer types in which specific collagen fiber organization patterns differ between benign and malignant tissue and also appear to be associated with disease stage, prognosis, treatment response, and other clinical features. There is great potential for developing image-based collagen fiber biomarkers for clinical applications, but its adoption in standard clinical practice is dependent on further translational and clinical evaluations. Here, we offer a comprehensive review of the current literature of fibrillar collagen structure and organization as a candidate cancer biomarker, and new perspectives on the challenges and next steps for researchers and clinicians seeking to exploit this information in biomedical research and clinical workflows. |
topic |
fibrillar collagen cancer prognosis tumor microenvironment extracellular matrix ECM |
url |
https://www.mdpi.com/2306-5354/8/2/17 |
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