Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
C-reactive protein is a pentameric protein secreted by the liver in response to injury and infection. Here Braiget al. show that conformational changes in CRP on the surface of monocyte-derived microvesicles enable binding of complement C1q and lead to activation of the complement cascade and aggrav...
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Bibliographic Details
Main Authors: |
David Braig,
Tracy L. Nero,
Hans-Georg Koch,
Benedict Kaiser,
Xiaowei Wang,
Jan R. Thiele,
Craig J. Morton,
Johannes Zeller,
Jurij Kiefer,
Lawrence A. Potempa,
Natalie A. Mellett,
Luke A. Miles,
Xiao-Jun Du,
Peter J. Meikle,
Markus Huber-Lang,
G. Björn Stark,
Michael W. Parker,
Karlheinz Peter,
Steffen U. Eisenhardt |
Format: | Article
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Language: | English |
Published: |
Nature Publishing Group
2017-01-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/ncomms14188
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