Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites
C-reactive protein is a pentameric protein secreted by the liver in response to injury and infection. Here Braiget al. show that conformational changes in CRP on the surface of monocyte-derived microvesicles enable binding of complement C1q and lead to activation of the complement cascade and aggrav...
Main Authors: | David Braig, Tracy L. Nero, Hans-Georg Koch, Benedict Kaiser, Xiaowei Wang, Jan R. Thiele, Craig J. Morton, Johannes Zeller, Jurij Kiefer, Lawrence A. Potempa, Natalie A. Mellett, Luke A. Miles, Xiao-Jun Du, Peter J. Meikle, Markus Huber-Lang, G. Björn Stark, Michael W. Parker, Karlheinz Peter, Steffen U. Eisenhardt |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2017-01-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/ncomms14188 |
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