Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy

Cardiac-specific catalase overexpression rescues anthrax lethal toxin-induced cardiac contractile dysfunction: role of oxidative stress and autophagy

<p>Abstract</p> <p>Background</p> <p>Lethal and edema toxins secreted by <it>Bacillus anthracis </it>during anthrax infection were found to incite serious cardiovascular complications. However, the underlying mechanisms in anthrax lethal toxin-induced cardia...

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Bibliographic Details
Main Authors: Kandadi Machender R, Yu Xuejun, Frankel Arthur E, Ren Jun
Format: Article
Language:English
Published: BMC 2012-11-01
Series:BMC Medicine
Subjects:
lethal toxin
cardiomyocyte
contractile function
autophagy
UPS
Online Access:http://www.biomedcentral.com/1741-7015/10/134

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