A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit
Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAB) infection outbreaks are difficult to control and sometimes require cohorting of CRAB-positive patients or temporary ward closure for environmental cleaning. We aimed at controlling the deadly 2018 CRAB outbreak in a 12 bed- inte...
Main Authors: | , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2021-08-01
|
Series: | Antimicrobial Resistance and Infection Control |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13756-021-00990-z |
id |
doaj-129690bf68f147f6b7ec16665a072602 |
---|---|
record_format |
Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Marianna Meschiari José-María Lòpez-Lozano Vincenzo Di Pilato Carola Gimenez-Esparza Elena Vecchi Erica Bacca Gabriella Orlando Erica Franceschini Mario Sarti Monica Pecorari Antonella Grottola Claudia Venturelli Stefano Busani Lucia Serio Massimo Girardis Gian Maria Rossolini Inge C. Gyssens Dominique L. Monnet Cristina Mussini |
spellingShingle |
Marianna Meschiari José-María Lòpez-Lozano Vincenzo Di Pilato Carola Gimenez-Esparza Elena Vecchi Erica Bacca Gabriella Orlando Erica Franceschini Mario Sarti Monica Pecorari Antonella Grottola Claudia Venturelli Stefano Busani Lucia Serio Massimo Girardis Gian Maria Rossolini Inge C. Gyssens Dominique L. Monnet Cristina Mussini A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit Antimicrobial Resistance and Infection Control Carbapenem-resistant Acinetobacter baumannii Intensive care unit Cycling radical environmental cleaning Infection control bundle Whole genome sequencing analysis |
author_facet |
Marianna Meschiari José-María Lòpez-Lozano Vincenzo Di Pilato Carola Gimenez-Esparza Elena Vecchi Erica Bacca Gabriella Orlando Erica Franceschini Mario Sarti Monica Pecorari Antonella Grottola Claudia Venturelli Stefano Busani Lucia Serio Massimo Girardis Gian Maria Rossolini Inge C. Gyssens Dominique L. Monnet Cristina Mussini |
author_sort |
Marianna Meschiari |
title |
A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit |
title_short |
A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit |
title_full |
A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit |
title_fullStr |
A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit |
title_full_unstemmed |
A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit |
title_sort |
five-component infection control bundle to permanently eliminate a carbapenem-resistant acinetobacter baumannii spreading in an intensive care unit |
publisher |
BMC |
series |
Antimicrobial Resistance and Infection Control |
issn |
2047-2994 |
publishDate |
2021-08-01 |
description |
Abstract Background Carbapenem-resistant Acinetobacter baumannii (CRAB) infection outbreaks are difficult to control and sometimes require cohorting of CRAB-positive patients or temporary ward closure for environmental cleaning. We aimed at controlling the deadly 2018 CRAB outbreak in a 12 bed- intensive care unit (ICU) including 9 beds in a 220 m2 open space. We implemented a new multimodal approach without ward closure, cohorting or temporarily limiting admissions. Methods A five-component bundle was introduced in 2018 including reinforcement of hand hygiene and sample extension of screening, application of contact precautions to all patients, enhanced environmental sampling and the one-time application of a cycling radical environmental cleaning and disinfection procedure of the entire ICU. The ICU-CRAB incidence density (ID), ICU alcohol-based hand rub consumption and antibiotic use were calculated over a period of 6 years and intervention time series analysis was performed. Whole genome sequencing analysis (WGS) was done on clinical and environmental isolates in the study period. Results From January 2013, nosocomial ICU-CRAB ID decreased from 30.4 CRAB cases per 1000 patients-days to zero cases per 1000 patients-days. Our intervention showed a significant impact (-2.9 nosocomial ICU-CRAB cases per 1000 bed-days), while no influence was observed for antibiotic and alcohol-based hand rub (AHR) consumption. WGS demonstrated that CRAB strains were clonally related to an environmental reservoir which confirms the primary role of the environment in CRAB ICU spreading. Conclusion A five-component bundle of continuous hand hygiene improvement, extended sampling at screening including the environment, universal contact precautions and a novel cycling radical environmental cleaning and disinfection procedure proved to be effective for permanently eliminating CRAB spreading within the ICU. Cohorting, admission restriction or ICU closure were avoided. |
topic |
Carbapenem-resistant Acinetobacter baumannii Intensive care unit Cycling radical environmental cleaning Infection control bundle Whole genome sequencing analysis |
url |
https://doi.org/10.1186/s13756-021-00990-z |
work_keys_str_mv |
AT mariannameschiari afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT josemarialopezlozano afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT vincenzodipilato afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT carolagimenezesparza afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT elenavecchi afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT ericabacca afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT gabriellaorlando afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT ericafranceschini afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT mariosarti afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT monicapecorari afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT antonellagrottola afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT claudiaventurelli afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT stefanobusani afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT luciaserio afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT massimogirardis afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT gianmariarossolini afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT ingecgyssens afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT dominiquelmonnet afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT cristinamussini afivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT mariannameschiari fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT josemarialopezlozano fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT vincenzodipilato fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT carolagimenezesparza fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT elenavecchi fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT ericabacca fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT gabriellaorlando fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT ericafranceschini fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT mariosarti fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT monicapecorari fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT antonellagrottola fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT claudiaventurelli fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT stefanobusani fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT luciaserio fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT massimogirardis fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT gianmariarossolini fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT ingecgyssens fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT dominiquelmonnet fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit AT cristinamussini fivecomponentinfectioncontrolbundletopermanentlyeliminateacarbapenemresistantacinetobacterbaumanniispreadinginanintensivecareunit |
_version_ |
1721199397242404864 |
spelling |
doaj-129690bf68f147f6b7ec16665a0726022021-08-22T11:43:23ZengBMCAntimicrobial Resistance and Infection Control2047-29942021-08-0110111310.1186/s13756-021-00990-zA five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unitMarianna Meschiari0José-María Lòpez-Lozano1Vincenzo Di Pilato2Carola Gimenez-Esparza3Elena Vecchi4Erica Bacca5Gabriella Orlando6Erica Franceschini7Mario Sarti8Monica Pecorari9Antonella Grottola10Claudia Venturelli11Stefano Busani12Lucia Serio13Massimo Girardis14Gian Maria Rossolini15Inge C. Gyssens16Dominique L. Monnet17Cristina Mussini18Infectious Disease Clinic, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaMedicine Preventive-Infection Control Team, Hospital Vega BajaDepartment of Surgical Sciences and Integrated Diagnostics, University of GenoaChief. Intensive Care Unit, Hospital Vega BajaHospital Hygiene and Infection Control, Azienda Ospedaliero-Universitaria Policlinico of ModenaInfectious Disease Clinic, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaInfectious Disease Clinic, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaInfectious Disease Clinic, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaClinical Microbiology Laboratory, Azienda Ospedaliero-Universitaria Policlinico of ModenaLaboratory of Virology and Molecular Biology, Azienda Ospedaliero-Universitaria Policlinico of ModenaLaboratory of Virology and Molecular Biology, Azienda Ospedaliero-Universitaria Policlinico of ModenaClinical Microbiology Laboratory, Azienda Ospedaliero-Universitaria Policlinico of ModenaAnesthesia and Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaAnesthesia and Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaAnesthesia and Intensive Care Unit, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaClinical Microbiology and Virology Unit, Florence Careggi University HospitalDepartment of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical CenterEuropean Centre for Disease Prevention and Control (ECDC)Infectious Disease Clinic, Azienda Ospedaliero-Universitaria Policlinico and University of Modena and Reggio EmiliaAbstract Background Carbapenem-resistant Acinetobacter baumannii (CRAB) infection outbreaks are difficult to control and sometimes require cohorting of CRAB-positive patients or temporary ward closure for environmental cleaning. We aimed at controlling the deadly 2018 CRAB outbreak in a 12 bed- intensive care unit (ICU) including 9 beds in a 220 m2 open space. We implemented a new multimodal approach without ward closure, cohorting or temporarily limiting admissions. Methods A five-component bundle was introduced in 2018 including reinforcement of hand hygiene and sample extension of screening, application of contact precautions to all patients, enhanced environmental sampling and the one-time application of a cycling radical environmental cleaning and disinfection procedure of the entire ICU. The ICU-CRAB incidence density (ID), ICU alcohol-based hand rub consumption and antibiotic use were calculated over a period of 6 years and intervention time series analysis was performed. Whole genome sequencing analysis (WGS) was done on clinical and environmental isolates in the study period. Results From January 2013, nosocomial ICU-CRAB ID decreased from 30.4 CRAB cases per 1000 patients-days to zero cases per 1000 patients-days. Our intervention showed a significant impact (-2.9 nosocomial ICU-CRAB cases per 1000 bed-days), while no influence was observed for antibiotic and alcohol-based hand rub (AHR) consumption. WGS demonstrated that CRAB strains were clonally related to an environmental reservoir which confirms the primary role of the environment in CRAB ICU spreading. Conclusion A five-component bundle of continuous hand hygiene improvement, extended sampling at screening including the environment, universal contact precautions and a novel cycling radical environmental cleaning and disinfection procedure proved to be effective for permanently eliminating CRAB spreading within the ICU. Cohorting, admission restriction or ICU closure were avoided.https://doi.org/10.1186/s13756-021-00990-zCarbapenem-resistant Acinetobacter baumanniiIntensive care unitCycling radical environmental cleaningInfection control bundleWhole genome sequencing analysis |