Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection
Abstract Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide is a major public health concern. Cancer patients are considered a vulnerable population to SARS-CoV-2 infection and may develop several COVID-19 symptoms. The heig...
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doaj-12a61651cf1e4c158d10a261d783118f2021-03-11T12:02:41ZengBMCJournal of Ovarian Research1757-22152021-02-0114111810.1186/s13048-021-00787-zComorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infectionSima Chaudhari0Satyajit Dey Pereira1Meshach Asare-Warehene2Ritam Naha3Shama Prasada Kabekkodu4Benjamin K. Tsang5Kapaettu Satyamoorthy6Department of Cell and Molecular Biology, Manipal School of Life Science, Manipal Academy of Higher EducationDepartment of Cell and Molecular Biology, Manipal School of Life Science, Manipal Academy of Higher EducationChronic Disease Program, Ottawa Hospital Research Institute and Department of Obstetrics & Gynecology and Cellular and Molecular Medicine, University of OttawaDepartment of Cell and Molecular Biology, Manipal School of Life Science, Manipal Academy of Higher EducationDepartment of Cell and Molecular Biology, Manipal School of Life Science, Manipal Academy of Higher EducationChronic Disease Program, Ottawa Hospital Research Institute and Department of Obstetrics & Gynecology and Cellular and Molecular Medicine, University of OttawaDepartment of Cell and Molecular Biology, Manipal School of Life Science, Manipal Academy of Higher EducationAbstract Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide is a major public health concern. Cancer patients are considered a vulnerable population to SARS-CoV-2 infection and may develop several COVID-19 symptoms. The heightened immunocompromised state, prolonged chronic pro-inflammatory milieu coupled with comorbid conditions are shared in both disease conditions and may influence patient outcome. Although ovarian cancer (OC) and COVID-19 are diseases of entirely different primary organs, both diseases share similar molecular and cellular characteristics in their microenvironment suggesting a potential cooperativity leading to poor outcome. In COVID-19 related cases, hospitalizations and deaths worldwide are lower in women than in males; however, comorbidities associated with OC may increase the COVID-19 risk in women. The women at the age of 50-60 years are at greater risk of developing OC as well as SARS-CoV-2 infection. Increased levels of gonadotropin and androgen, dysregulated renin-angiotensin-aldosterone system (RAAS), hyper-coagulation and chronic inflammation are common conditions observed among OC and severe cases of COVID-19. The upregulation of common inflammatory cytokines and chemokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-2, IL-6, IL-10, interferon-γ-inducible protein 10 (IP-10), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), macrophage colony-stimulating factor (M-CSF), among others in the sera of COVID-19 and OC subjects suggests potentially similar mechanism(s) involved in the hyper-inflammatory condition observed in both disease states. Thus, it is conceivable that the pathogenesis of OC may significantly contribute to the potential infection by SARS-CoV-2. Our understanding of the influence and mechanisms of SARS-CoV-2 infection on OC is at an early stage and in this article, we review the underlying pathogenesis presented by various comorbidities of OC and correlate their influence on SARS-CoV-2 infection.https://doi.org/10.1186/s13048-021-00787-zOvarian cancerrisk factorSARS-CoV-2InflammationHormones |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sima Chaudhari Satyajit Dey Pereira Meshach Asare-Warehene Ritam Naha Shama Prasada Kabekkodu Benjamin K. Tsang Kapaettu Satyamoorthy |
spellingShingle |
Sima Chaudhari Satyajit Dey Pereira Meshach Asare-Warehene Ritam Naha Shama Prasada Kabekkodu Benjamin K. Tsang Kapaettu Satyamoorthy Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection Journal of Ovarian Research Ovarian cancer risk factor SARS-CoV-2 Inflammation Hormones |
author_facet |
Sima Chaudhari Satyajit Dey Pereira Meshach Asare-Warehene Ritam Naha Shama Prasada Kabekkodu Benjamin K. Tsang Kapaettu Satyamoorthy |
author_sort |
Sima Chaudhari |
title |
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection |
title_short |
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection |
title_full |
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection |
title_fullStr |
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection |
title_full_unstemmed |
Comorbidities and inflammation associated with ovarian cancer and its influence on SARS-CoV-2 infection |
title_sort |
comorbidities and inflammation associated with ovarian cancer and its influence on sars-cov-2 infection |
publisher |
BMC |
series |
Journal of Ovarian Research |
issn |
1757-2215 |
publishDate |
2021-02-01 |
description |
Abstract Coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) worldwide is a major public health concern. Cancer patients are considered a vulnerable population to SARS-CoV-2 infection and may develop several COVID-19 symptoms. The heightened immunocompromised state, prolonged chronic pro-inflammatory milieu coupled with comorbid conditions are shared in both disease conditions and may influence patient outcome. Although ovarian cancer (OC) and COVID-19 are diseases of entirely different primary organs, both diseases share similar molecular and cellular characteristics in their microenvironment suggesting a potential cooperativity leading to poor outcome. In COVID-19 related cases, hospitalizations and deaths worldwide are lower in women than in males; however, comorbidities associated with OC may increase the COVID-19 risk in women. The women at the age of 50-60 years are at greater risk of developing OC as well as SARS-CoV-2 infection. Increased levels of gonadotropin and androgen, dysregulated renin-angiotensin-aldosterone system (RAAS), hyper-coagulation and chronic inflammation are common conditions observed among OC and severe cases of COVID-19. The upregulation of common inflammatory cytokines and chemokines such as tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-2, IL-6, IL-10, interferon-γ-inducible protein 10 (IP-10), granulocyte colony-stimulating factor (G-CSF), monocyte chemoattractant protein-1 (MCP-1), macrophage colony-stimulating factor (M-CSF), among others in the sera of COVID-19 and OC subjects suggests potentially similar mechanism(s) involved in the hyper-inflammatory condition observed in both disease states. Thus, it is conceivable that the pathogenesis of OC may significantly contribute to the potential infection by SARS-CoV-2. Our understanding of the influence and mechanisms of SARS-CoV-2 infection on OC is at an early stage and in this article, we review the underlying pathogenesis presented by various comorbidities of OC and correlate their influence on SARS-CoV-2 infection. |
topic |
Ovarian cancer risk factor SARS-CoV-2 Inflammation Hormones |
url |
https://doi.org/10.1186/s13048-021-00787-z |
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