Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

Efficient biosynthesis of heterodimeric C3-aryl pyrroloindoline alkaloids

The hexahydropyrrolo[2, 3-b]indole (HPI) framework is found in many natural products. Here, the authors discover a P450 enzyme and develop a whole-cell biocatalysis system that produces the HPI naseseazine C (NAS-C) and 30 NAS-C analogs, several of which show neuroprotective properties.

Bibliographic Details
Main Authors: Wenya Tian, Chenghai Sun, Mei Zheng, Jeffrey R. Harmer, Mingjia Yu, Yanan Zhang, Haidong Peng, Dongqing Zhu, Zixin Deng, Shi-Lu Chen, Mehdi Mobli, Xinying Jia, Xudong Qu
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06528-z

Internet

https://doi.org/10.1038/s41467-018-06528-z

Similar Items