Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress

Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between...

Full description

Bibliographic Details
Main Authors: Jereme G. Spiers, Hsiao-Jou Cortina eChen, Conrad eSernia, Nickolas A. Lavidis
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-01-01
Series:Frontiers in Neuroscience
Subjects:
Corticosterone
Oxidative Stress
Reactive Oxygen Species
Hypothalamic-Pituitary-Adrenal Axis
stress.
redox status
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00456/full
Description
Summary:Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.
ISSN:1662-453X

Similar Items