Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress
Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between...
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00456/full |
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doaj-12bb995b573f4416b62f78f5e955bef32020-11-25T00:49:21ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-01-01810.3389/fnins.2014.00456124588Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stressJereme G. Spiers0Hsiao-Jou Cortina eChen1Conrad eSernia2Nickolas A. Lavidis3The University of QueenslandThe University of QueenslandThe University of QueenslandThe University of QueenslandGlucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure.http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00456/fullCorticosteroneOxidative StressReactive Oxygen SpeciesHypothalamic-Pituitary-Adrenal Axisstress.redox status |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jereme G. Spiers Hsiao-Jou Cortina eChen Conrad eSernia Nickolas A. Lavidis |
spellingShingle |
Jereme G. Spiers Hsiao-Jou Cortina eChen Conrad eSernia Nickolas A. Lavidis Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress Frontiers in Neuroscience Corticosterone Oxidative Stress Reactive Oxygen Species Hypothalamic-Pituitary-Adrenal Axis stress. redox status |
author_facet |
Jereme G. Spiers Hsiao-Jou Cortina eChen Conrad eSernia Nickolas A. Lavidis |
author_sort |
Jereme G. Spiers |
title |
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress |
title_short |
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress |
title_full |
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress |
title_fullStr |
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress |
title_full_unstemmed |
Activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress |
title_sort |
activation of the hypothalamic-pituitary-adrenal stress axis induces cellular oxidative stress |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2015-01-01 |
description |
Glucocorticoids released from the adrenal gland in response to stress-induced activation of the hypothalamic-pituitary-adrenal (HPA) axis induce activity in the cellular reduction-oxidation (redox) system. The redox system is a ubiquitous chemical mechanism allowing the transfer of electrons between donor/acceptors and target molecules during oxidative phosphorylation while simultaneously maintaining the overall cellular environment in a reduced state. The objective of this review is to present an overview of the current literature discussing the link between HPA axis-derived glucocorticoids and increased oxidative stress, particularly focussing on the redox changes observed in the hippocampus following glucocorticoid exposure. |
topic |
Corticosterone Oxidative Stress Reactive Oxygen Species Hypothalamic-Pituitary-Adrenal Axis stress. redox status |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00456/full |
work_keys_str_mv |
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