Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats
Abstract Objective Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine o...
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doaj-12c52dceb48a4cf98b88bb731ce92c902020-11-25T02:52:37ZengBMCBMC Research Notes1756-05002020-04-011311610.1186/s13104-020-05073-7Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar ratsMuhamudu Kalange0Miriam Nansunga1Keneth Iceland Kasozi2Josephine Kasolo3Jackline Namulema4Jovile Kasande Atusiimirwe5Emanuel Tiyo Ayikobua6Fred Ssempijja7Edson Ireeta Munanura8Kevin Matama9Ibrahim Semuyaba10Gerald Zirintunda11Alfred Omachonu Okpanachi12Department of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Physiology, College of Health Sciences, Makerere UniversityDepartment of Physiology, Faculty of Medicine, Uzima University College CUEADepartment of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Anatomy, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Pharmacy, College of Health Sciences, Makerere UniversityDepartment of Therapeutics and Toxicology, School of Pharmacy, Kampala International University Western CampusDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityDepartment of Animal Production, Faculty of Agriculture and Animal Sciences, Busitema University Arapai CampusDepartment of Physiology, Faculty of Biomedical Sciences, Kampala International UniversityAbstract Objective Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline). Group V was the negative control consisting of healthy rats. Results Antimalarial combination therapies were associated with a high gastric ulcer index than a single antimalarial agent, Artesunate. In addition, levels of MDA were significantly higher in the combination of therapies while levels of GSH were lower in comparison to Artesunate and the negative control. Microscopically, antimalarial combination therapies were associated with severe inflammation and tissue damage than Artesunate in the gastric mucosa showing that antimalarial combination therapies exert their toxic effects through oxidative stress mechanisms, and this leads to cellular damage. Findings in this study demonstrate a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries.http://link.springer.com/article/10.1186/s13104-020-05073-7AntimalarialsPharmacodynamics of antimalarial agentsMalaria in developing countriesGastric ulcers |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Muhamudu Kalange Miriam Nansunga Keneth Iceland Kasozi Josephine Kasolo Jackline Namulema Jovile Kasande Atusiimirwe Emanuel Tiyo Ayikobua Fred Ssempijja Edson Ireeta Munanura Kevin Matama Ibrahim Semuyaba Gerald Zirintunda Alfred Omachonu Okpanachi |
spellingShingle |
Muhamudu Kalange Miriam Nansunga Keneth Iceland Kasozi Josephine Kasolo Jackline Namulema Jovile Kasande Atusiimirwe Emanuel Tiyo Ayikobua Fred Ssempijja Edson Ireeta Munanura Kevin Matama Ibrahim Semuyaba Gerald Zirintunda Alfred Omachonu Okpanachi Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats BMC Research Notes Antimalarials Pharmacodynamics of antimalarial agents Malaria in developing countries Gastric ulcers |
author_facet |
Muhamudu Kalange Miriam Nansunga Keneth Iceland Kasozi Josephine Kasolo Jackline Namulema Jovile Kasande Atusiimirwe Emanuel Tiyo Ayikobua Fred Ssempijja Edson Ireeta Munanura Kevin Matama Ibrahim Semuyaba Gerald Zirintunda Alfred Omachonu Okpanachi |
author_sort |
Muhamudu Kalange |
title |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats |
title_short |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats |
title_full |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats |
title_fullStr |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats |
title_full_unstemmed |
Antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male Wistar rats |
title_sort |
antimalarial combination therapies increase gastric ulcers through an imbalance of basic antioxidative-oxidative enzymes in male wistar rats |
publisher |
BMC |
series |
BMC Research Notes |
issn |
1756-0500 |
publishDate |
2020-04-01 |
description |
Abstract Objective Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. The aim of this study was to investigate the effects of Artesunate-Amodiaquine and Artemether-Lumefantrine on ulcer induction. Malondialdehyde (MDA), reduced glutathione (GSH) and major histological changes in male Wistar rats following ulcer induction using Indomethacin were investigated. Gastric ulcers were in four groups; Group I was administered Artesunate, group II received Artesunate-Amodiaquine, group III received Artemether-Lumefantrine, and group IV was a positive control (normal saline). Group V was the negative control consisting of healthy rats. Results Antimalarial combination therapies were associated with a high gastric ulcer index than a single antimalarial agent, Artesunate. In addition, levels of MDA were significantly higher in the combination of therapies while levels of GSH were lower in comparison to Artesunate and the negative control. Microscopically, antimalarial combination therapies were associated with severe inflammation and tissue damage than Artesunate in the gastric mucosa showing that antimalarial combination therapies exert their toxic effects through oxidative stress mechanisms, and this leads to cellular damage. Findings in this study demonstrate a need to revisit information on the pharmacodynamics of major circulating antimalarial agents in developing countries. |
topic |
Antimalarials Pharmacodynamics of antimalarial agents Malaria in developing countries Gastric ulcers |
url |
http://link.springer.com/article/10.1186/s13104-020-05073-7 |
work_keys_str_mv |
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