Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process

Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process

A Brønsted acidic ionic liquid, 3-(N,N-dimethyldodecylammonium) propanesulfonic acid hydrogen sulphate ([DDPA][HSO4]), has been successfully applied to catalyze sequential oxidation of aromatic alcohols with NaNO3 followed by their condensation with dicarbonyl compound and ammonium acetate. The corr...

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Main Authors: Xiaobing Liu, Bin Liu
Format: Article
Language:English
Published: Hindawi Limited 2017-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2017/5646908
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spelling doaj-12e3bb63bacc4cecadbe920129d4d3d62020-11-24T21:16:22ZengHindawi LimitedJournal of Chemistry2090-90632090-90712017-01-01201710.1155/2017/56469085646908Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation ProcessXiaobing Liu0Bin Liu1School of Chemistry and Chemical Engineering, Jinggangshan University, Ji’an 343009, ChinaSchool of Basic Medicine and Pharmacy, Jinggangshan University, Ji’an 343009, ChinaA Brønsted acidic ionic liquid, 3-(N,N-dimethyldodecylammonium) propanesulfonic acid hydrogen sulphate ([DDPA][HSO4]), has been successfully applied to catalyze sequential oxidation of aromatic alcohols with NaNO3 followed by their condensation with dicarbonyl compound and ammonium acetate. The corresponding pyridine analogues of Hantzsch 1,4-dihydropyridines could be obtained as a major product with high yields by the multicomponent reaction. The present work utilizing alcohols instead of aldehyde in Hantzsch reaction is a valid and green alternative to the classical synthesis of the corresponding pyridine analogues of Hantzsch 1,4-dihydropyridines.http://dx.doi.org/10.1155/2017/5646908
collection DOAJ
language English
format Article
sources DOAJ
author Xiaobing Liu
Bin Liu
spellingShingle Xiaobing Liu
Bin Liu
Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
Journal of Chemistry
author_facet Xiaobing Liu
Bin Liu
author_sort Xiaobing Liu
title Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
title_short Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
title_full Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
title_fullStr Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
title_full_unstemmed Hantzsch Reaction Starting Directly from Alcohols through a Tandem Oxidation Process
title_sort hantzsch reaction starting directly from alcohols through a tandem oxidation process
publisher Hindawi Limited
series Journal of Chemistry
issn 2090-9063
2090-9071
publishDate 2017-01-01
description A Brønsted acidic ionic liquid, 3-(N,N-dimethyldodecylammonium) propanesulfonic acid hydrogen sulphate ([DDPA][HSO4]), has been successfully applied to catalyze sequential oxidation of aromatic alcohols with NaNO3 followed by their condensation with dicarbonyl compound and ammonium acetate. The corresponding pyridine analogues of Hantzsch 1,4-dihydropyridines could be obtained as a major product with high yields by the multicomponent reaction. The present work utilizing alcohols instead of aldehyde in Hantzsch reaction is a valid and green alternative to the classical synthesis of the corresponding pyridine analogues of Hantzsch 1,4-dihydropyridines.
url http://dx.doi.org/10.1155/2017/5646908
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AT binliu hantzschreactionstartingdirectlyfromalcoholsthroughatandemoxidationprocess
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