Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms

Regulation of TSHR Expression in the Thyroid and Thymus May Contribute to TSHR Tolerance Failure in Graves' Disease Patients via Two Distinct Mechanisms

Graves' disease (GD) involves the presence of agonistic auto-antibodies against the thyrotropin receptor (TSHR), which are responsible for the clinical symptoms. While failure of TSHR tolerance is central to GD pathogenesis, the process leading to this failure remains poorly understood. Two mec...

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Bibliographic Details
Main Authors: Ana Marín-Sánchez, Daniel Álvarez-Sierra, Oscar González, Ana Lucas-Martin, Alicia Sellés-Sánchez, Francesc Rudilla, Emma Enrich, Roger Colobran, Ricardo Pujol-Borrell
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
Graves' disease
TSHR
tolerance
splicing isoforms
thymus
thyroid
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01695/full

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