Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.

Microbial translocation is associated with increased monocyte activation and dementia in AIDS patients.

Elevated plasma lipopolysaccharide (LPS), an indicator of microbial translocation from the gut, is a likely cause of systemic immune activation in chronic HIV infection. LPS induces monocyte activation and trafficking into brain, which are key mechanisms in the pathogenesis of HIV-associated dementi...

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Main Authors: Petronela Ancuta, Anupa Kamat, Kevin J Kunstman, Eun-Young Kim, Patrick Autissier, Alysse Wurcel, Tauheed Zaman, David Stone, Megan Mefford, Susan Morgello, Elyse J Singer, Steven M Wolinsky, Dana Gabuzda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-06-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2424175?pdf=render

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