Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial
Objective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex) combined with constraint-induced movement therapy for treatment of stroke patients. Design. Sixty patients were randomly distributed into 3 groups: Group A, a...
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doaj-1306bc116db9477685a2654947713cda2020-11-24T22:35:24ZengHindawi LimitedRehabilitation Research and Practice2090-28672090-28752017-01-01201710.1155/2017/68425496842549Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled TrialSuellen M. Andrade0Larissa M. Batista1Lídia L. R. F. Nogueira2Eliane A. de Oliveira3Antonio G. C. de Carvalho4Soriano S. Lima5Jordânia R. M. Santana6Emerson C. C. de Lima7Bernardino Fernández-Calvo8Federal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilFederal University of Paraíba, João Pessoa, PB, BrazilObjective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex) combined with constraint-induced movement therapy for treatment of stroke patients. Design. Sixty patients were randomly distributed into 3 groups: Group A, anodal stimulation on premotor cortex and constraint-induced movement therapy; Group B, anodal stimulation on primary motor cortex and constraint-induced movement therapy; Group C, sham stimulation and constraint-induced movement therapy. Evaluations involved analysis of functional independence, motor recovery, spasticity, gross motor function, and muscle strength. Results. A significant improvement in primary outcome (functional independence) after treatment in the premotor group followed by primary motor group and sham group was observed. The same pattern of improvement was highlighted among all secondary outcome measures regarding the superior performance of the premotor group over primary motor and sham groups. Conclusions. Premotor cortex can contribute to motor function in patients with severe functional disabilities in early stages of stroke. This study was registered in ClinicalTrials.gov database (NCT 02628561).http://dx.doi.org/10.1155/2017/6842549 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Suellen M. Andrade Larissa M. Batista Lídia L. R. F. Nogueira Eliane A. de Oliveira Antonio G. C. de Carvalho Soriano S. Lima Jordânia R. M. Santana Emerson C. C. de Lima Bernardino Fernández-Calvo |
spellingShingle |
Suellen M. Andrade Larissa M. Batista Lídia L. R. F. Nogueira Eliane A. de Oliveira Antonio G. C. de Carvalho Soriano S. Lima Jordânia R. M. Santana Emerson C. C. de Lima Bernardino Fernández-Calvo Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial Rehabilitation Research and Practice |
author_facet |
Suellen M. Andrade Larissa M. Batista Lídia L. R. F. Nogueira Eliane A. de Oliveira Antonio G. C. de Carvalho Soriano S. Lima Jordânia R. M. Santana Emerson C. C. de Lima Bernardino Fernández-Calvo |
author_sort |
Suellen M. Andrade |
title |
Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial |
title_short |
Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial |
title_full |
Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial |
title_fullStr |
Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial |
title_full_unstemmed |
Constraint-Induced Movement Therapy Combined with Transcranial Direct Current Stimulation over Premotor Cortex Improves Motor Function in Severe Stroke: A Pilot Randomized Controlled Trial |
title_sort |
constraint-induced movement therapy combined with transcranial direct current stimulation over premotor cortex improves motor function in severe stroke: a pilot randomized controlled trial |
publisher |
Hindawi Limited |
series |
Rehabilitation Research and Practice |
issn |
2090-2867 2090-2875 |
publishDate |
2017-01-01 |
description |
Objective. We compared the effects of transcranial direct current stimulation at different cortical sites (premotor and motor primary cortex) combined with constraint-induced movement therapy for treatment of stroke patients. Design. Sixty patients were randomly distributed into 3 groups: Group A, anodal stimulation on premotor cortex and constraint-induced movement therapy; Group B, anodal stimulation on primary motor cortex and constraint-induced movement therapy; Group C, sham stimulation and constraint-induced movement therapy. Evaluations involved analysis of functional independence, motor recovery, spasticity, gross motor function, and muscle strength. Results. A significant improvement in primary outcome (functional independence) after treatment in the premotor group followed by primary motor group and sham group was observed. The same pattern of improvement was highlighted among all secondary outcome measures regarding the superior performance of the premotor group over primary motor and sham groups. Conclusions. Premotor cortex can contribute to motor function in patients with severe functional disabilities in early stages of stroke. This study was registered in ClinicalTrials.gov database (NCT 02628561). |
url |
http://dx.doi.org/10.1155/2017/6842549 |
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