STAT5 as a Key Protein of Erythropoietin Signalization
Erythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and...
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doaj-13143cfd052b4cd29c53519f733e2b8d2021-07-15T15:38:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-07-01227109710910.3390/ijms22137109STAT5 as a Key Protein of Erythropoietin SignalizationZuzana Tóthová0Jana Tomc1Nataša Debeljak2Peter Solár3Institute of Medical Biology, Faculty of Medicine, P.J. Šafárik University in Košice, 04011 Košice, SlovakiaMedical Centre for Molecular Biology, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaMedical Centre for Molecular Biology, Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, 1000 Ljubljana, SloveniaInstitute of Medical Biology, Faculty of Medicine, P.J. Šafárik University in Košice, 04011 Košice, SlovakiaErythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK. The canonical EPOR/JAK2/STAT5 pathway is a known regulator of differentiation, proliferation, and cell survival of erythroid progenitors. In addition, its role in the protection of other cells, including cancer cells, is under intense investigation. The involvement of EPOR/JAK2/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. The transcriptomics, proteomics, and epigenetic studies reviewed in this article provide a detailed understanding of EPO signalization. Advances in this area of research may be useful for improving the efficacy of EPO therapy in hematologic disorders, as well as in cancer treatment.https://www.mdpi.com/1422-0067/22/13/7109STAT5erythropoietinerythropoietin receptor |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Zuzana Tóthová Jana Tomc Nataša Debeljak Peter Solár |
spellingShingle |
Zuzana Tóthová Jana Tomc Nataša Debeljak Peter Solár STAT5 as a Key Protein of Erythropoietin Signalization International Journal of Molecular Sciences STAT5 erythropoietin erythropoietin receptor |
author_facet |
Zuzana Tóthová Jana Tomc Nataša Debeljak Peter Solár |
author_sort |
Zuzana Tóthová |
title |
STAT5 as a Key Protein of Erythropoietin Signalization |
title_short |
STAT5 as a Key Protein of Erythropoietin Signalization |
title_full |
STAT5 as a Key Protein of Erythropoietin Signalization |
title_fullStr |
STAT5 as a Key Protein of Erythropoietin Signalization |
title_full_unstemmed |
STAT5 as a Key Protein of Erythropoietin Signalization |
title_sort |
stat5 as a key protein of erythropoietin signalization |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2021-07-01 |
description |
Erythropoietin (EPO) acts on multiple tissues through its receptor EPOR, a member of a cytokine class I receptor superfamily with pleiotropic effects. The interaction of EPO and EPOR triggers the activation of several signaling pathways that induce erythropoiesis, including JAK2/STAT5, PI3K/AKT, and MAPK. The canonical EPOR/JAK2/STAT5 pathway is a known regulator of differentiation, proliferation, and cell survival of erythroid progenitors. In addition, its role in the protection of other cells, including cancer cells, is under intense investigation. The involvement of EPOR/JAK2/STAT5 in other processes such as mRNA splicing, cytoskeleton reorganization, and cell metabolism has been recently described. The transcriptomics, proteomics, and epigenetic studies reviewed in this article provide a detailed understanding of EPO signalization. Advances in this area of research may be useful for improving the efficacy of EPO therapy in hematologic disorders, as well as in cancer treatment. |
topic |
STAT5 erythropoietin erythropoietin receptor |
url |
https://www.mdpi.com/1422-0067/22/13/7109 |
work_keys_str_mv |
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