The major vault protein is dispensable for zebrafish organ regeneration

The major vault protein is dispensable for zebrafish organ regeneration

As the main constituent of the largest cellular ribonucleoprotein complex, the evolutionary highly conserved major vault protein (MVP) has been proposed play vital roles in the regeneration of multiple organs. In current study, we use a mvp knockout zebrafish line recently generated to characterize...

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Bibliographic Details
Main Authors: Xue Zhang, Yuxi Yang, Xiaoxue Bu, Yuanyuan Wei, Xin Lou
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:Heliyon
Subjects:
Major vault protein
Regeneration
Zebrafish
Knockout
Anti-apoptotic effect
Biological sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020322659
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spelling doaj-131a62eecc4b4beea774145b6067f25a2020-12-09T06:38:36ZengElsevierHeliyon2405-84402020-11-01611e05422The major vault protein is dispensable for zebrafish organ regenerationXue Zhang0Yuxi Yang1Xiaoxue Bu2Yuanyuan Wei3Xin Lou4Medical School, Nanjing University, ChinaMedical School, Nanjing University, ChinaMedical School, Nanjing University, ChinaMedical School, Nanjing University, ChinaCorresponding author.; Medical School, Nanjing University, ChinaAs the main constituent of the largest cellular ribonucleoprotein complex, the evolutionary highly conserved major vault protein (MVP) has been proposed play vital roles in the regeneration of multiple organs. In current study, we use a mvp knockout zebrafish line recently generated to characterize the function of MVP during organ regeneration. We found the regenerative capacity of heart, spinal cord and fin is preserved in mvp knockout zebrafish. Further experiments demonstrated in injured mvp knockout zebrafish, the cell death is enhanced while the transcriptome landscape is largely unchanged. These data showed MVP acts as an anti-apoptotic factor at early phase of injury response while plays a dispensable role in the regenerative programs in zebrafish.http://www.sciencedirect.com/science/article/pii/S2405844020322659Major vault proteinRegenerationZebrafishKnockoutAnti-apoptotic effectBiological sciences
collection DOAJ
language English
format Article
sources DOAJ
author Xue Zhang
Yuxi Yang
Xiaoxue Bu
Yuanyuan Wei
Xin Lou
spellingShingle Xue Zhang
Yuxi Yang
Xiaoxue Bu
Yuanyuan Wei
Xin Lou
The major vault protein is dispensable for zebrafish organ regeneration
Heliyon
Major vault protein
Regeneration
Zebrafish
Knockout
Anti-apoptotic effect
Biological sciences
author_facet Xue Zhang
Yuxi Yang
Xiaoxue Bu
Yuanyuan Wei
Xin Lou
author_sort Xue Zhang
title The major vault protein is dispensable for zebrafish organ regeneration
title_short The major vault protein is dispensable for zebrafish organ regeneration
title_full The major vault protein is dispensable for zebrafish organ regeneration
title_fullStr The major vault protein is dispensable for zebrafish organ regeneration
title_full_unstemmed The major vault protein is dispensable for zebrafish organ regeneration
title_sort major vault protein is dispensable for zebrafish organ regeneration
publisher Elsevier
series Heliyon
issn 2405-8440
publishDate 2020-11-01
description As the main constituent of the largest cellular ribonucleoprotein complex, the evolutionary highly conserved major vault protein (MVP) has been proposed play vital roles in the regeneration of multiple organs. In current study, we use a mvp knockout zebrafish line recently generated to characterize the function of MVP during organ regeneration. We found the regenerative capacity of heart, spinal cord and fin is preserved in mvp knockout zebrafish. Further experiments demonstrated in injured mvp knockout zebrafish, the cell death is enhanced while the transcriptome landscape is largely unchanged. These data showed MVP acts as an anti-apoptotic factor at early phase of injury response while plays a dispensable role in the regenerative programs in zebrafish.
topic Major vault protein
Regeneration
Zebrafish
Knockout
Anti-apoptotic effect
Biological sciences
url http://www.sciencedirect.com/science/article/pii/S2405844020322659
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AT yuxiyang themajorvaultproteinisdispensableforzebrafishorganregeneration
AT xiaoxuebu themajorvaultproteinisdispensableforzebrafishorganregeneration
AT yuanyuanwei themajorvaultproteinisdispensableforzebrafishorganregeneration
AT xinlou themajorvaultproteinisdispensableforzebrafishorganregeneration
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AT xiaoxuebu majorvaultproteinisdispensableforzebrafishorganregeneration
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